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Zeolite hemostatic dressings and preparation method and application thereof

The technology of hemostatic dressing and zeolite is applied in the field of high exchange degree Ca-A type zeolite hemostatic dressing and its preparation, which can solve the problems such as the undisclosed synthetic zeolite process, the pharmacological effect and the function disclosure, and achieve no sensitization reaction, no cell Toxic, non-skin irritating effects

Active Publication Date: 2008-01-16
深圳泰明嘉业药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The zeolite used in this patent application can be natural zeolite, also can be synthetic zeolite, but does not disclose the technology of concrete synthetic zeolite
At the same time, the patent application did not make any disclosure about its pharmaceutical effects and functions.

Method used

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  • Zeolite hemostatic dressings and preparation method and application thereof

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preparation example Construction

[0039] One embodiment of the present invention relates to a method for preparing the zeolite hemostatic dressing, the method comprising the following steps:

[0040] 1) Mix 4A zeolite, binder, lignin and optional molecular sieve activation powder together to make seeds and granulate, polish, and then sieve particles with a particle size of 0.2-1.0 mm;

[0041] 2) After drying the particles obtained in step 1), activate and calcinate at about 300-800 °C;

[0042] 3) reacting the calcined particles with an alkaline solution for a suitable period of time at about 50-150° C., followed by washing;

[0043] 4) repeatedly exchange the particles obtained in step 3) with the calcium ion-containing solution, and then repeatedly wash and dry with deionized water;

[0044] 5) The particles obtained in step 4) are activated and calcined at about 300-800° C. for a second time.

[0045] Step 1) can be granulated by a granulation technique well known to those skilled in the art. The granul...

Embodiment 1

[0054] Example 1 Preparation of zeolite hemostatic dressing

[0055] The zeolite used in the present invention is the 4A zeolite provided by China Kaolin Co., Ltd. The zeolite was tested by X-ray diffractometer in the testing laboratory of Zhengzhou Light Metal Research Institute. See Figure 1 for the X-ray diffraction pattern.

[0056] In gained 1000g zeolite, add 400g kaolin (product of China Kaolin Company), 40g lignin (Jilin Province Chenning Paper Co., Ltd.) and add 120g molecular sieve activation powder as dispersant, spray sodium carboxymethyl cellulose in the pelletizer The solution is made into spherical particles, sieved with a 0.2mm sieve and a 1.0mm sieve into particles of 0.2-1.0mm, and then activated and calcined at 600°C.

[0057] The product obtained by activation calcination was reacted in sodium hydroxide solution at 95°C for 2 hours. After solid-liquid separation, and then washing with hot water, the residual alkali contained in it is washed clean.

[00...

Embodiment 2

[0059] Embodiment 2 Hemostatic powder composition test

[0060] The testing laboratory of Zhengzhou Light Metal Research Institute was responsible for testing, and X-fluorescence spectrometer was used to test the composition of zeolite hemostatic dressings. The analysis result of X-fluorescence spectrometer shows that the zeolite hemostatic dressing of the present invention is mainly composed of Al 2 O 3 About 25% to 35%, SiO 2 About 30% to 40%, and CaO about 10% to 18%.

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Abstract

The invention relates to the high degree of exchange Ca-A type zeolite hemostasis dressing and the preparation method and the purpose. The zeolite hemostasis dressing of the invention containing the zeolite has fast hemostasis speed, and has no bacterium, no pyrogen, no cell toxicity, no hypersensitive reaction and no skin irritation, the using is convenient and the cost is low.

Description

technical field [0001] The present invention relates to the field of hemostatic dressings. More specifically, the present invention relates to a high exchange degree Ca-A type zeolite hemostatic dressing and its preparation method and use. Background technique [0002] Blood is a fluid tissue containing plasma and red blood cells, white blood cells, microparticles, and platelets dispersed in the plasma, which also contains water, acids, lipids, soluble electrolytes, and proteins. A special protein suspended in plasma is fibrinogen, whose function is, in the case of bleeding, it can react with water and thrombin to form blood-insoluble fibrin and further polymerize to form a clot, preventing bleeding. Under normal circumstances, when the animal body (including the human body) is injured and bleeds, the fibrinogen in the blood can exert the above-mentioned functions and play the role of hemostasis. [0003] In general, bleeding caused by small wounds can be suppressed by the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18
Inventor 古鸿雁窦桂芳欧阳茂海周旭
Owner 深圳泰明嘉业药业有限公司
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