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Method for preparation of cross-linking hyaluronic acid sodium jelly glue implanted in eyes

A technology for cross-linking hyaluronic acid and sodium hyaluronate, which is applied in the field of medicine, achieves good resistance to enzymatic degradation, improves filtration and maintains filtration channels, and simplifies production steps.

Inactive Publication Date: 2007-12-05
凌沛学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no public report on the use of hydrazide compounds to cross-link SH to prepare gels for eye implants.

Method used

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  • Method for preparation of cross-linking hyaluronic acid sodium jelly glue implanted in eyes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Dissolve 0.125g SH (average molecular weight 1.415 million Daltons) in 5ml Tris-HCl (pH4.5) buffer solution, add ADH12.5mg, and mix well; another 30mg of EDCI is dissolved in 1ml Tris-HCl (pH4.5 ) buffer solution, then poured into the above mixed solution of SH and ADH, mixed quickly, and slowly poured into the gap between the two glass plates fixed in advance, after the reaction solution filled the gap, place the glass plate horizontally , and react for 2 to 24 hours until the reaction solution is completely gelled.

[0022] The two glass plates are rectangular small glass pieces of the same size, with a thickness of about 0.3mm and an area of ​​about 3cm×7cm. The gap between the glass plates is fixed by placing a small gasket of a certain thickness between the two small glass pieces. Realization, the small spacer is a glass sheet or hard non-toxic plastic with a thickness of 0.45mm and a size of about 0.5cm×3cm. It is inserted between two small rectangular glasses alo...

Embodiment 2

[0025] Dissolve 0.125g SH (average molecular weight: 370,000 Daltons) in 5ml Tris-HCl (pH4.0) buffer solution, add ADH21.7mg, mix well; dissolve EDCI 30mg in 1ml Tris-HCl (pH4.0) buffer solution, then poured into the above mixed solution of SH and ADH, mixed quickly, and slowly poured between two glass plates with a gap width of 0.47mm. After the reaction solution filled the gap, place the glass plate horizontally, and react 2 to 24 hours, until the reaction solution is completely gelled. The preparation of the glass plates is basically the same as that in Example 1, except that the thickness of the small spacers sandwiched between the glass plates is 0.47 mm. The purification, cutting, packaging and sterilization of the gel are the same as in Example 1.

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Abstract

The present invention relates to preparation process of cross-linked sodium hyaluronate gel as eye implant. The process of preparing the cross-linked sodium hyaluronate gel includes the following steps: pouring the reactant liquid comprising sodium hyaluronate, hydrazide compound, carbodiimide as carboxyl group activator and proper buffer into the gap between two plates to form gel in certain thickness; purifying; cutting; packing and sterilizing. The cross-linked sodium hyaluronate gel is used as eye implant, especially for the non-penetrating glaucoma treating operation, to prevent adhesion of the aqueous humor filtering passage, raise the filtering effect and control the post-operational intraocular pressure.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a preparation method of cross-linked sodium hyaluronate (hereinafter referred to as SH) gel and its application in the preparation of eye implant materials. Background technique [0002] Hyaluronic acid (hereinafter referred to as HA) is composed of (1-β-4) D-glucuronic acid and (1-β-3) N-acetyl-D-glucosamine disaccharide units repeatedly linked It is a chain polyanionic mucopolysaccharide, which is an important component of skin, vitreous body, synovial fluid and cartilage tissue, and has unique physical and chemical properties and biological functions. The sodium salt of HA is mostly used in commercial products, that is, SH. SH can be used as a viscoelastic agent in ophthalmic surgery and orthopedic surgery, in the treatment of osteoarthritis and rheumatoid arthritis, and in the prevention of postoperative adhesions. It can also be used as a drug medium in various pharmaceutical preparat...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/36A61K31/728A61F9/00A61P27/06
Inventor 凌沛学贺艳丽陈建英刘杰汪敏荣晓花
Owner 凌沛学
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