Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Knub thermotherapy based on exothermic chemical reaction

A chemical reaction and tumor technology, applied in the field of tumor hyperthermia, can solve the problems of incompetence, high price, difficult operation, etc., and achieve the effect of reducing thermal damage and easy operation.

Inactive Publication Date: 2007-12-05
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although radiofrequency hyperthermia can heat deep tumors, it needs water to cool the local area, and the subcutaneous fat is prone to overheating and pain, resulting in hard joints and difficult operation
Ultrasonic focused hyperthermia has strong penetrating power and can treat deep tumors. However, due to the limitation of ultrasound itself, it cannot penetrate gas-containing tissues or bones, so the scope of application is greatly limited.
[0004] For all existing tumor hyperthermia methods, the core problem to be solved is how to direct the heat to the tumor target tissue, and heat the tumor tissue to an effective killing temperature without damaging normal tissue. There is still no good solution to the problem
In addition, a common feature of the thermotherapy equipment based on the above method is that the structure is complex, the price is generally very expensive, and the operation is complicated, so the treatment cost is very high

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Knub thermotherapy based on exothermic chemical reaction
  • Knub thermotherapy based on exothermic chemical reaction
  • Knub thermotherapy based on exothermic chemical reaction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Fig. 1-1 is a schematic diagram of an interventional injection device used in the present invention; Fig. 1-2 is a cross-sectional view of A-A of Fig. 1-1, wherein 1 is a puncture needle;

[0040] Fig. 2 is a schematic structural view of the injection device in Fig. 1; wherein 1 is a puncture needle, and 2 is a syringe;

[0041] Fig. 3 is a schematic diagram of implementing the exothermic chemical reaction-based tumor hyperthermia method of the present invention; wherein 2 is a syringe, 5 is a tumor target tissue, and 3 is an elevating bed.

[0042]Concentrated hydrochloric acid and sodium hydroxide solutions are selected as the liquid reactants for injection, so that two solutions need to be injected into the target tissue. The feasibility of this embodiment is illustrated by calculation below:

[0043] Inject 100 grams of 40% NaOH solution and 100 grams of 37.5% concentrated hydrochloric acid into the target tissue, so that a total of 200 grams of the solution is inj...

Embodiment 2

[0051] The reactants are selected from concentrated hydrochloric acid and sodium hydroxide solution.

[0052] Inject 100 grams of NaOH solution with a mass percent concentration of 40% and 150 grams of concentrated hydrochloric acid with a mass percent concentration of 37.5% to the target tissue respectively, so that a total of 250 grams of the solution is injected into the tumor target tissue, then It is still reasonable to think that this part of the heat release is concentrated in 1000 grams of tissue. The molar ratio of concentrated hydrochloric acid and sodium hydroxide injected in this example is 1.5:1. After the reaction, hydrochloric acid remains in the tissue, but hydrochloric acid is a substance existing in the human body (such as gastric acid contains hydrochloric acid), so it will not It is harmful to the human body, and hydrochloric acid also has a certain killing effect on tumor cells through chemical effects.

[0053] It can be seen from Example 1 that in this ...

Embodiment 3

[0058] The reactants are selected from concentrated hydrochloric acid and sodium hydroxide solution.

[0059] Inject 100 grams of 40% NaOH solution and 200 grams of 37.5% concentrated hydrochloric acid into the target tissue, so that a total of 300 grams of the solution is injected into the tumor target tissue. It is still reasonable to concentrate part of the heat release in 1000 grams of tissue. The molar ratio of the concentrated hydrochloric acid and sodium hydroxide injected in this example is 2:1. After the reaction, hydrochloric acid remains in the tissue, but hydrochloric acid is a substance existing in the human body (such as gastric acid contains hydrochloric acid), so it will not It is harmful to the human body, and hydrochloric acid also has a certain killing effect on tumor cells through chemical effects.

[0060] It can be seen from Example 1 that in this case, 57.32 kJ of heat will be released into 1000 grams of tissue and 300 grams of solution after the reacti...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
The inside diameter ofaaaaaaaaaa
Lengthaaaaaaaaaa
Lengthaaaaaaaaaa
Login to View More

Abstract

The present invention is thermal tumor treating process based on exothermal chemical reaction, and chemical reactants capable of producing exothermal reaction is injected through microtrauma injection to the targeted tumor region for producing chemical reaction releasing heat killing the tumor. The chemical reactants may be concentrated hydrochloric acid solution and sodium hydroxide solution in the molar ratio of 1-2 injected to the targeted tumor region, or concentrated sulfuric acid in 10-200 g injected to the targeted tumor region and water injected into the tumor tissue. The thermal tumor treating process has microtrauma, high safety, high treating effect, simple operation and other advantages, and may be combined easily with other tumor treating process.

Description

technical field [0001] The invention relates to a tumor hyperthermia method, in particular to a tumor hyperthermia method based on an exothermic chemical reaction directly applied to a tumor target area. Background technique [0002] Tumors, especially malignant tumors, are one of the most important killers that threaten human health and life, and surgical resection, radiotherapy and chemotherapy are considered to be the most effective treatments so far. However, resection will cause limb mutilation, and radiotherapy and chemotherapy will cause physical and mental damage due to side effects, all of which will inevitably reduce the survival rate and quality of life of patients. Therefore, it has always been a research hotspot in the field of biomedical engineering to seek minimally invasive treatment methods that can effectively kill tumor cells and ensure less damage and less toxic side effects. [0003] Tumor hyperthermia uses heat to treat tumors. It has developed rapidly...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61B18/06A61B17/34A61M5/178
Inventor 邓中山刘静周一欣
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products