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Organism indwelling support

A biological and biodegradable technology, applied in the field of biological indwelling stents, can solve the problems of low degree of sustained release, inability to obtain sustained release of restenosis rate, etc., and achieve the effect of easy provision.

Inactive Publication Date: 2007-10-10
KANEKA CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the degree of sustained release disclosed in the present technology is relatively low, and the sustained release required to reduce the rate of restenosis after stent placement cannot be obtained.

Method used

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  • Organism indwelling support
  • Organism indwelling support

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] The main body of the stent was produced by laser cutting a cylindrical tube of stainless steel (SUS316L) with an inner diameter of 1.50 mm and an outer diameter of 1.80 mm into a stent pattern, and electrolytically polishing it. The expanded view of the used bracket is shown in FIG. 1 , and the schematic diagram is shown in FIG. 2 . The length of the stent was 13 mm, the thickness was 120 μm, and the nominal diameter after expansion was 3.5 mm. Since the stent is a so-called balloon-expandable type, it is a type of stent that is expanded and indwelling by using a balloon catheter having a balloon near the distal end of the catheter. Balloon-expandable stents are installed in a state in which the balloon of the balloon catheter is partially deflated, and after being delivered to the target site, the stent is expanded and indwelling by expanding the balloon.

[0063] Lactic acid-glycolic acid copolymer (product number: 85DG065, Absorbale Polymers International company, l...

Embodiment 2

[0067] In addition to making a solution of drug concentration / polymer concentration=0.75wt% / 0.50wt%, forming an inner layer with a polymer weight of 66 μg and a drug weight of 100 μg per stent (drug / polymer weight ratio=1.52 ) except that it was produced in the same manner as in Example 1.

[0068] The total polymer weight of the inner and outer layers of each obtained stent was 258 μg, and the drug weight was 150 μg (drug / polymer weight ratio=0.58).

Embodiment 3

[0070] In addition to making a solution of drug concentration / polymer concentration=0.05wt% / 0.50wt%, forming an outer layer with a polymer weight of 500 μg and a drug weight of 50 μg per stent (drug / polymer weight ratio=0.10 ) except that it was produced in the same manner as in Example 1.

[0071] The total polymer weight of the inner and outer layers of each obtained stent was 600 μg, and the drug weight was 150 μg (drug / polymer weight ratio=0.25).

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PUM

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Abstract

It is intended to easily provide a stent for placement in body which can hold an increased amount of a drug without causing cracking or peeling in the coating layer with the dilation of the stent and from which the drug can be sustainedly released as far as possible. Namely, a stent for placement in body having a coating layer mainly comprising a drug and a polymer in at least a part of the stent surface wherein the coating layer consists of an inner layer and an outer layer, the weight ratio of drug / polymer, which is defined based on the weights of the drug and the polymer contained in each layer, of the inner layer is higher than that of the outer layer, and the outer layer contains an efficacious amount of the drug.

Description

technical field [0001] The present invention relates to a stent for indwelling a living body for medical use for expansion treatment of a stenotic part of a blood vessel. Background technique [0002] Today, narrowing of blood vessels due to arteriosclerosis is one of the major health problems we face. It is known that particularly when coronary arteries of the heart are narrowed, serious diseases such as angina pectoris and myocardial infarction are caused, and the risk of death is extremely high. As one of the treatment methods for these vascular stenosis sites, there is angioplasty (PTA, PTCA) which dilates the stenosis site by dilating a small balloon in the blood vessel, and is widely used because it is a minimally invasive treatment method. However, when angioplasty is used, the probability of recurrence of stenosis (restenosis) is high. As a method of reducing the frequency of restenosis recurrence (restenosis rate), atrectomy, laser therapy, radiation therapy, etc....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/84A61M29/02A61F2/915A61L31/00
CPCA61F2/915A61L31/148A61L2300/608A61L2300/416A61F2250/0035A61L31/10A61F2210/0076A61L2300/61A61F2002/91525A61F2002/9155A61L31/16A61F2002/91533A61L2300/606A61F2230/0054A61F2250/0067A61L2300/41A61F2/91A61F2/82A61L27/34A61M29/02A61L27/54
Inventor 西出拓司滝口友辉中野良二深谷浩平河津昌司
Owner KANEKA CORP
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