Medicine composition including active substrates extracted from Sang Huang, the preparing method and the application in the producing of medicine thereof
A technology of active substances and compositions, which can be applied to pharmaceutical compositions of active substances, preparation of anticancer drugs, hypotensive drugs and hypoglycemic drugs, and the field of immunomodulatory drugs, can solve the problem that the efficacy and activity of heteropolysaccharides need to be improved problem, to achieve significant anti-tumor activity, simple process, and the effect of enhancing immune activity
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Embodiment 1
[0037] A method for preparing active substances extracted from Phellinus Phellinus comprises the following steps:
[0038] i. The preparation method of the water extract of the fruiting body of Phellinus Phellinus: crush 400 g of the fruiting body of Phellinus Phellinus, pass through a 60-mesh sieve, use 3000 ml of water to reflux extract at a temperature of 90 ° C for 8 hours, filter, and repeat the above extraction process for the solid residue After 3 times, the filtrates were combined, concentrated under reduced pressure to a volume of 50ml, added 200ml of ethanol, placed at 4°C for 24 hours, filtered, washed with 30ml of acetone and 30ml of ethanol, and freeze-dried to obtain 28g; The polysaccharide content is 65%.
[0039] ii. Polysaccharide PT 1 and proteoglycan PT 2 The preparation method of Phellinus Phellinus fruiting body: take the water extract of Phellinus chinensis fruiting body and add 15ml of sodium phosphate (5mmol) buffer solution with a pH of 7.7 to 5g of ...
Embodiment 2
[0059] The method for preparing the active substance extracted from Phellinus Phellinus is basically the same as that in Example 1, except that the method used to measure the protein content is the Folin phenol reagent method.
Embodiment 3
[0061] A tablet containing a mixture of active substances extracted from Phellinus Phellinus, the active substance is PT 1 and PT 2 A mixture of 1:3 by weight (PT1 and PT 2 Preparation method is as embodiment 1), and prescription is as follows:
[0062] Phellinus active substance 200g
[0063] Lactose 200g
[0064] Appropriate amount of starch slurry
[0065] Sodium carboxymethyl starch 10g
[0067] Total production of 1000 pieces
[0068] Preparation method: Phellinus active substance, lactose, and sodium carboxymethyl starch are ground separately and passed through a 60-mesh sieve, weighed according to the above prescription, and the ingredients are mixed evenly. Under stirring, the starch slurry is used to make a soft material, and passed through a 18-mesh Sieve to make wet granules and dry at 60°C for 4 hours, then sieve and granulate, add magnesium stearate, mix evenly, and press into tablets.
[0069] Usage and dosage of the present...
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