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Medical plants intensifier having antifungal activity and drug tolerance of reversion azole antifungal agents

A synergist and drug technology, applied in the direction of antifungal agents, drug combination, drug delivery, etc., can solve problems such as increase, and achieve the effect of increasing the effective rate, reducing the fatality rate, and reducing the dosage

Inactive Publication Date: 2007-09-12
广州雪利昂生物科技有限公司
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  • Summary
  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

However, with the long-term and widespread use of azole drugs, strains resistant to azole drugs have gradually appeared, and there is a clear increase trend, and treatment failures caused by drug-resistant strain infections are also increasing day by day

Method used

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Effect test

Embodiment

[0038] According to different routes of administration, the medicinal plant synergist for reversing the multidrug resistance of the antifungal activity of azoles and the pharmaceutical composition containing the synergist can be prepared according to the following formula:

[0039] 1. Topical medication:

[0040] (1) The medicinal plant synergist for reversing the antifungal activity of multidrug resistance of azoles is formulated into an ointment with a ratio of 0.01-5% and a fat-soluble medium (such as vaseline) and applied to the affected part; or in the same ratio Add an appropriate amount of emulsifier (such as phospholipid, drug: phospholipid = 10-100: 1) to make an aqueous solution for external application or flushing of the affected part; or make other dosage forms, such as gel, coating, spray, lotion, containing chemicals, etc.

[0041] (2) Preparation of Tetrandrine Ointment: Purified medicinal Tetrandrine powder was selected and mixed with heated and melted vaselin...

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PUM

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Abstract

The present invention discloses the application of tetrandine, matrine, ligustrazine or elemene as synergist for reverting the activity of azole medicines for treating mycotic infection of mammal in resisting fungal drug resistance, and corresponding medicine composition containing the synergist. The botanic medicine synergist of tetrandine, matrine, ligustrazine or elemene is applied together with antifungal azole medicine for treating mycotic infection of mammal, and this can raise treating effect and reduce the dosage of antifungal azole medicine and corresponding untoward reaction.

Description

technical field [0001] The present invention relates to the application of medicinal plants in reversing multidrug resistance (MDR) of azole antifungal activity, and the present invention further relates to a medicinal plant synergist for reversing multidrug resistance of azole antifungal activity And an antifungal pharmaceutical composition comprising the synergist. Background technique [0002] In recent years, with the widespread use of broad-spectrum antibiotics, corticosteroids, immunosuppressants, and chemotherapy drugs, the widespread development of organ transplantation and catheter technology, and the sharp increase in the number of HIV infections, the infection rate and fatality rate of fungi have also increased significantly . Alvarez-Lerma et al. investigated 1562 cases in 641 intensive care units and found that 15.9% of patients could be isolated from pathogenic fungi, and 7.7% of patients had concurrent fungal clinical infections, of which Candida albicans acc...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61K31/4748A61K31/015A61K9/00A61P31/10A61P43/00A61K31/4164A61K31/4375A61K31/4196A61K31/4174A61K31/506
Inventor 张宏张革化
Owner 广州雪利昂生物科技有限公司
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