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Preparing method of ethyl cellulose micro-and nano-particles loaded with probucol

A technology of ethyl cellulose and micro-nano particles, which is applied in the direction of making medicines into special physical or taking forms of devices, etc., can solve the problems of unstable drug release rate, large burst release of microcapsules, and insufficient absorption. , to achieve the effect of adjustable slow release performance, no particle adhesion, and stable release

Inactive Publication Date: 2007-09-12
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Probucol (probucol, probucol) is mainly used as a cholesterol-lowering and anti-atherosclerotic drug, which has a good preventive and therapeutic effect on atherosclerosis, but the oral absorption is less than 10%, and long-term medication can cause accumulation
[0004] Find through literature retrieval to prior art, Li Yaolan etc. have published the paper entitled " the preparation research of Tea Dove Sustained Release Microcapsules " in " Chinese Medicinal Materials " (2000 35 volumes 5 phase 281-285 pages), with B The base cellulose is used as the capsule material, and the tea polyphenols sustained-release microcapsules are prepared by the emulsion solvent evaporation technology. The microcapsules have a certain sustained-release effect, but the sudden release of the microcapsules is relatively large, and the release rate of the drug is unstable.

Method used

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  • Preparing method of ethyl cellulose micro-and nano-particles loaded with probucol
  • Preparing method of ethyl cellulose micro-and nano-particles loaded with probucol
  • Preparing method of ethyl cellulose micro-and nano-particles loaded with probucol

Examples

Experimental program
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Effect test

Embodiment 1

[0019] Dissolve 3g ethylcellulose in 60ml 95% ethanol, add 34% HNO 3 20ml of the solution was refluxed for 1 hour, cooled to room temperature, and then 300ml of distilled water was added, a white precipitate was formed in the solution, suction filtered, the precipitate was washed with distilled water several times until the pH of the eluate was 7.0, and dried at 40°C to obtain White powdery low molecular weight ethyl cellulose with a viscosity average molecular weight of 37560.

Embodiment 2

[0021] Dissolve 3g ethyl cellulose in 60ml, 95% ethanol, add 34% HNO 3 Solution 20ml, reflux for 2.5h, cool to room temperature, then add 300ml of distilled water, a white precipitate product is formed in the solution, filter with suction, wash the precipitate repeatedly with distilled water until the pH of the eluate is 7.0, and dry at 40°C to obtain a white Powdered low molecular weight ethyl cellulose with a viscosity average molecular weight of 20198.

Embodiment 3

[0023] Dissolve 3g ethyl cellulose in 60ml, 95% ethanol, add 34% HNO 3 Solution 20ml, reflux for 4 hours, cool to room temperature, then add 300ml of distilled water, a white precipitate product is formed in the solution, filter with suction, wash the precipitate with distilled water repeatedly until the pH of the eluate is 7.0, and dry at 40°C to obtain a white powder Like low molecular weight ethyl cellulose with a viscosity average molecular weight of 7394.

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Abstract

The preparation process of micron and nanometer probucol supporting ethyl cellulose particle belongs to the field of controlled and slow releasing medicine preparation. The present invention adopts water solution of sodium dodecyl sulfate as the water phase and dichloromethane solution of ethyl cellulose and probucol as the oil phase, adds the oil phase into the water phase, emulsifies and eliminates dichloromethane to obtain micron and nanometer ethyl cellulose particle; and washes the particle with distilled water to neutrality and decompression dries at normal temperature for curing to obtain micron and nanometer probucol supporting ethyl cellulose particle. The present invention has simple operation, and the obtained micron and nanometer probucol supporting ethyl cellulose particle may reach nanometer level size.

Description

technical field [0001] The invention relates to a preparation method in the technical field of medicines, in particular to a preparation method of ethyl cellulose micro-nano particles loaded with probucol. Background technique [0002] Slow and controlled release technology means that in a specific system, certain measures are taken to reduce the release rate of a certain active agent, so that the active agent in the system can maintain an effective concentration within a certain period of time. There are still some problems in the study of sustained and controlled release pharmaceuticals, mainly the choice of carrier materials, such as how to deal with the relationship between drug release rate and stability, how to reduce the toxic and side effects of carrier materials, etc. [0003] Probucol (probucol, probucol) is mainly used as a cholesterol-lowering and anti-atherosclerosis drug. It has good preventive and therapeutic effects on atherosclerosis, but its oral absorption...

Claims

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Application Information

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IPC IPC(8): A61J3/02
Inventor 万锕俊张悦粤高礼李慧丽
Owner SHANGHAI JIAO TONG UNIV
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