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Multi-phase chiral metal catalyst and its production

A metal catalyst and catalyst technology, applied in the direction of catalyst activation/preparation, carbon monoxide reaction preparation, catalyst carrier, etc., can solve the problems of heterogeneous hydrogen chiral formylation catalyst and related technology research, and achieve the effect of maintaining catalytic performance

Inactive Publication Date: 2007-09-05
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
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Problems solved by technology

However, there are few researches on heterogeneous hydrochiral formylation catalysts and related technologies based on inorganic supports.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (1), 10.0 g of acid-washed, alcohol-washed, roasted silicon oxide (180 mesh, main pore diameter 9.7 nm) was vacuum activated at 180 ° C for 3 hours, and about 20 ml of rhodium chloride aqueous solution (containing 0.25 mg of chlorine hydrate Rhodium chloride), impregnated by incipient wetness method in ultrasonic vibration for 4 hours, and vacuum rotary evaporation to remove excess water. The obtained catalyst precursor was dried in a vacuum drying oven at 100° C. for about 24 hours, and then calcined in a quartz sample tube furnace at 300° C. for 3 hours to obtain the catalyst precursor. (2) Take 0.05g of the aforementioned catalyst precursor and reductively activate it in hydrogen (50ml / min) at 400°C for 3 hours. After the temperature drops to room temperature, introduce 3.2mg of chiral phosphine ligand (R)-BINAP under the protection of argon 5ml of toluene solution modification. Catalyst A modified in situ with chiral ligands was obtained.

Embodiment 2

[0044] The same as in Example 1, except that step (3) is added, after soaking at 60° C. for 3 hours, hydrogen purging is carried out to evaporate the solvent to obtain chiral pre-modified catalyst B.

Embodiment 3

[0046] Same as Example 1, except that the mesoporous carrier in step (1) is replaced with 3.4nm MCM-41. Catalyst C modified in situ with chiral ligands was obtained.

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Abstract

A multi-phase chiral metal catalyst used for preparing chiral aldehyde product by catalytic asymmetric hydroformylation of olefin is composed of the homogenous chiral ligand chosen from C-2 symmetric chiral biphosphine ligand, N-contained phosphinate type chiral ligand, biphosphinte-type ligand, etc, the active component chosen from Rh, Pt, Ru and Ir, and carrier. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a heterogeneous chiral catalyst for asymmetric hydroformylation of olefins to prepare optically active aldehydes. [0002] The present invention also relates to a method for preparing the above-mentioned catalyst. [0003] The invention also relates to the use of the above-mentioned catalysts. Background technique [0004] In the past ten years, people's demand for single-enantiomer chiral compounds is huge and increasing year by year. This demand is mainly reflected in the fields of medicine, pesticides and fine chemicals. In recent years, the sales volume of single enantiomer medicines in the world has grown rapidly at about 8% per year, and will exceed 172 billion US dollars in 2005. Asymmetric catalysis plays an important role in all methods to obtain single enantiomer compounds, and this method has been widely used in many types of asymmetric synthesis reactions. So far, the research field of synthesizing chiral drugs a...

Claims

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Application Information

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IPC IPC(8): B01J31/22B01J32/00B01J37/02B01J37/16C07C45/49
CPCY02P20/50
Inventor 李灿韩涤非李晓红
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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