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Use of hypericum japonicum in preparation of medicine against nephritis and renal insufficiency

A kind of technology of Helicoverpa chinensis and kidney function, which is applied in the field of medicine and achieves the effect of good control effect

Active Publication Date: 2007-09-05
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] It has been reported in the literature that the effect of C. chinensis on liver protection, antibacterial, hemostasis, antimalarial, antitumor, antiviral, antioxidative, and immune function improvement has not yet been used to treat nephritis and renal insufficiency. to report

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] This example is a drug directly prepared from the raw medicinal materials of the grassland:

[0025] Take the raw medicinal material of the traditional Chinese medicine Dianthus prairie, that is, the dried whole herb of Hypericum japonicum Thunb. After purification, it is pulverized according to the conventional method, sieved, and made into a fine powder of Dermatium japonicum with a particle size of 60-200, packed into capsules, and sterilized. Bacteria, subpackage and serve.

Embodiment 2

[0027] The present embodiment is the preparation of the ethanol extract A:

[0028] Cut the Herba Dirt into 2-3 cm long sections, extract three times with 30% ethanol under reflux, each time for 2 hours, combine the extracts through a filter cloth, and concentrate under reduced pressure to a specific gravity of about 1.20, 2-5 Refrigerate at ℃ for more than 24 hours, centrifuge, take the upper layer and concentrate it to a small volume (1ml contains about 2g of raw medicinal materials), let it cool, and put it on the AB-8 macroporous resin column that has been treated at a flow rate of 1ml / min; A large amount of deionized water, 5-30% ethanol, and 50-95% ethanol were eluted, qualitatively identified with concentrated sulfuric acid, and the ethanol eluate that showed a positive reaction was collected, concentrated under reduced pressure and vacuum-dried to obtain the main flavonoids The flavonoid extract A of the similar substances has a yield greater than 1%, and a total flavo...

Embodiment 3

[0030] The present embodiment is the preparation of the ethanol extract B:

[0031] Cut the herb of Dirnaceae into 2-3 cm long sections, extract three times with 90% ethanol under reflux, the first time is 3 hours, the second time and the third time are respectively 1 hour, the extracts are coarsely filtered through filter cloth, combined, and decompressed Concentrate to a specific gravity of about 1.01, refrigerate at 2-5°C for more than 24 hours, centrifuge, take the supernatant and concentrate it to a small volume (1ml contains about 2g of raw medicinal materials), let it cool, and put it on the treated polyamide column at a flow rate of 1ml / min; elute with about 15 times column volume of deionized water and 60%-95% ethanol respectively, qualitatively identify with concentrated sulfuric acid, collect the ethanol eluate showing positive reaction, concentrate under reduced pressure and vacuum dry , that is to obtain the flavonoids mainly containing flavonoids extract B, the ...

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Abstract

An application of Japanese St. john's-wort herb or its extract in preparing the medicines for preventing nephritis and renal insufficiency is disclosed.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a new application of a known traditional Chinese medicine, Dillia chinensis, in the preparation of medicines for preventing and treating diseases. Background technique [0002] Nephritis is a group of glomerular diseases caused by various etiologies, which can be manifested clinically as proteinuria, hematuria, edema, and hypertension. There are many types of nephritis, the most common of which are acute (glomerular) nephritis, chronic (glomerular) nephritis, and pyelonephritis. Once suffering from nephritis, if it is not properly controlled, with the development of the disease, renal function decline and renal dysfunction will gradually appear, ranging from loss of labor force, affecting the normal work and study life of the patient; severe loss of life, seriously endangering human health . [0003] Acute and chronic glomerulonephritis is an allergic disease that...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P13/12
Inventor 米军夏隆江闫光华
Owner SICHUAN GOODDOCTOR PANXI PHARMA
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