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Antifungal drug delivery

An antifungal and fungal infection technology, applied in the direction of antibacterial drugs, drug delivery, antifungal agents, etc., can solve problems that hinder the efficacy of local drug delivery

Inactive Publication Date: 2007-08-22
马塞尔・尼姆尼 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately the topical administration of these drugs and their concomitant efficacy is hampered by the lack of suitable carriers or forms of permeation routes capable of enhancing the actual solubility of water-insoluble drugs

Method used

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Examples

Experimental program
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Embodiment Construction

[0039] The following detailed description is of the best mode currently contemplated for carrying out the invention. The description is not intended to be limiting, but serves only to illustrate the general principles of the invention, the scope of which is best defined by the claims.

[0040] One embodiment of the present invention is an antifungal composition for topical application to the skin and nails. Generally, the composition contains:

[0041] (1) allylamine antifungal compounds;

[0042] (2) fatty alcohols substituted with aromatic substituents in which the allylamine antifungal compound is soluble to the extent that the allylamine antifungal compound is in solution at an effective concentration for topical administration;

[0043] (3) lower aliphatic alcohols in which aromatic alcohols are soluble; and

[0044] (4) Water or a water-compatible solvent mixture.

[0045] Typically, the allylamine antifungal compound is terbinafine. However, the allylamine antifung...

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PUM

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Abstract

An improved antifungal composition for topical application to the skin and nails comprises: (1) an allylamine antifungal compound; (2) an aliphatic alcohol substituted with an aromatic substituent in which the allylamine antifungal compound is soluble to a degree that a therapeutically effective concentration of the allylamine antifungal compound can be applied topically in solution; (3) a lower aliphatic alcohol in which the aromatic alcohol is soluble; and (d) water or a water-compatible solvent mixture. The allylamine antifungal compound can be terbinafine or naftifine. The aliphatic alcohol substituted with an aromatic substituent can be benzyl alcohol or phenethyl alcohol. The lower aliphatic alcohol can be ethyl alcohol or isopropyl alcohol. In an alternative, the composition can further comprise an additional antifungal compound. Another aspect of the invention is a method for treatment of a fungal infection of skin or nails comprising administering the antifungal composition of the present invention topically to the skin or nails in an amount therapeutically effective to treat the fungal infection.

Description

field of invention [0001] The present invention relates to a method of delivery of antifungal drugs, in particular hydrophobic antifungal compounds such as terbinafine. Background of the invention [0002] Fingernails and toenails are very susceptible to fungal skin infections caused by fungal invasion of the nails of humans and other animals. There are a number of fungi that can cause such infections, such as Trichophyton rubrum, Microsporum canis, T. mentagrophytes, T. interdigitale, and other known fungi. Their treatment, especially when it concerns the nails, requires the oral administration of one or more known antifungal drugs, such as griseofulvin, ketoconazole, terbinafine, ciclopiridone and others. The general rule is that if these infections are not treated early, they will become difficult to treat, and even though oral administration can cure the disease, relapses often occur. Furthermore, since most of these compounds are poorly absorbed through the gastroint...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/41A61K31/135A61K31/13A61P31/10A61K9/00A61K31/137
CPCA61K31/343A61K9/0014A61K31/137A61K31/4174A61K31/496A61K45/06A61K47/10A61P17/00A61P31/04A61P31/10A61K2300/00
Inventor 马塞尔·尼姆尼阿南特·潘迪亚
Owner 马塞尔・尼姆尼
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