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Method of modulating laser-accelerated protons for radiationtherapy

A proton, prescription technology used in radiation therapy, therapy, X-ray/gamma-ray/particle radiation therapy, etc.

Inactive Publication Date: 2007-08-08
FOX CHASE CANCER CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This tip has no control over the photon depth dose distribution, which is preset by the photon energy spectrum from the accelerator head

Method used

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  • Method of modulating laser-accelerated protons for radiationtherapy
  • Method of modulating laser-accelerated protons for radiationtherapy
  • Method of modulating laser-accelerated protons for radiationtherapy

Examples

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Embodiment

[0109] The examples described below represent 2.5D modulation / optimization of uniform prescription doses that provide multi-energy proton beamlets for prostate tumors. In these embodiments, the energy is first modulated to obtain the SOBP of each beamlet and then the intensity of each modulated beam is optimized to achieve dose consistency (ie, uniform prescribed dose).

[0110]Energy modulation calculation. As mentioned earlier (Fourkal et al., 2002), the particle grid (PIC) (Birdsall, et al., 1985, "Plasma Physics via Computer Simulation", McGraw-Hill Book Company, Singapore) was used to determine the simulation code of high-power lasers and solids Interaction of high-density foils. The problem of dimensionality and the importance of nonlinear and dynamic effects make it difficult for analytical methods to provide a detailed description of the laser-plasma interaction. In this case, PIC simulation is an effective tool, which can clearly show the complex problems of laser-plasma ...

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PUM

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Abstract

Methods of optimizing a laser-accelerated proton radiation dose to a targeted region are disclosed. Disclosed methods include providing a plurality of modulated polyenergetic proton beamlets and irradiating the targeted region with the plurality of modulated beamlets.

Description

[0001] Cross-references to related applications [0002] This patent application requires the United States Provisional Patent Application 60 / 526,436 filed on December 3, 2003, which is hereby incorporated by reference in its entirety, and the international patent application filed on June 2, 2004, which is hereby incorporated by reference in its entirety. Priority of PCT / US2004 / 017081. [0003] Government rights [0004] The work to complete the disclosed invention was fully or partially funded by federal funds from the National Institutes of Health. The government may have certain rights in the invention under the NIH contract number CA78331. Invention field [0005] The present invention relates to a method for regulating and modulating high-energy cations used in ion radiotherapy. In particular, the present invention relates to a method for prescribing and preparing high-energy protons used in proton radiotherapy. The present invention also relates to a treatment optimization m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/00A61N5/00A61N5/10G21K5/04H01S
CPCA61N5/1031A61N2005/1087G21K2201/00G21K5/04A61N2005/1088A61N5/1043
Inventor 马长明尤金·S·富尔卡尔
Owner FOX CHASE CANCER CENTER
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