Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparing method of alpha-ketoglutaric acid-arginine salt and its use for treating hepatic disease

A technology of ketoglutaric acid and arginine salt, which is applied in the field of preparation of α-ketoglutaric acid-arginine salt preparation, can solve the instability of α-ketoglutaric acid and reduce α-ketoglutaric acid Pharmacological effects, instability, etc.

Inactive Publication Date: 2007-08-08
BEIJING JIASHILIANBO PHARM SCI & TECH
View PDF0 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

α-ketoglutarate is unstable under alkaline conditions and is easy to form a salt with organic bases, so α-ketoglutarate is unstable in alkaline environments such as the human intestinal tract, thereby reducing the activity of α-ketoglutarate pharmacological effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Add 10g of α-ketoglutarate and 5g of arginine into the aqueous solution, stir at room temperature until dissolved, and wait until the reaction is complete to obtain a reaction solution, which is directly freeze-dried to obtain the raw material drug, namely α-ketoglutarate- arginine salt.

Embodiment 2

[0079] Add 8g of α-ketoglutarate and 6g of arginine into water, heat to dissolve at 60°C, filter, cool the filtrate to crystallize, filter, collect the solid, and obtain the raw material drug, ie, α-ketoglutarate-arginine salt.

Embodiment 3

[0081] Add 5g of α-ketoglutaric acid and 7g of arginine into the aqueous solution, stir at room temperature until dissolved, and wait until the reaction is complete to obtain a reaction solution, which is directly freeze-dried to obtain the raw material drug, namely α-ketoglutarate- arginine salt.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an alpha-ketoglutaric acid-arginine salt, the preparing process and use thereof, wherein the salt is prepared through combining alpha-ketoglutaric acid and arginine with a preferred ratio of 1:1 and 1:2. Pharmacological experiment shows that, the salt can be used for treating liver damages.

Description

technical field [0001] The invention belongs to the field of medicine and pharmacy, and in particular relates to a preparation method of an alpha-ketoglutarate-arginine salt preparation and its application in treating liver diseases. Background technique [0002] α-ketoglutarate-arginine salt, also known as arginine-α-ketoglutarate, AKG, is a white powder, easily soluble in water. α-Ketoglutaric acid-arginine salt has the ability to store endogenous glutamine and improve glutamine synthesis, which can promote protein synthesis in critically ill patients and maintain patient weight and energy. [0003] α-Ketoglutaric acid is an important substance in the metabolism of substances and energy in organisms. It is the hub of the metabolic connection and interconversion of sugar, lipids, and certain amino acids. 2 And the key substance of the main pathway of energy. α-ketoglutaric acid is unstable under alkaline conditions and is easy to form a salt with organic bases, so α-ketog...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/194A61K31/198A61K9/08A61K9/10A61K9/14A61K9/19A61K9/20A61K9/46A61K9/48A61K47/16A61P1/16
Inventor 温守明喻蓉
Owner BEIJING JIASHILIANBO PHARM SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com