Liposome of astragaloside IV and its medicinal preparation

Abstract

The invention relates to a astragaloside liposome and method for preparing same, wherein the liposome is prepared from astragaloside, phosphatide and lipophilic additives, the weight ratio of phosphatide and astragaloside is 0.5:1-100:1, the weight ratio of phosphatide and lipophilic additives is 1:1-50:1. The liposome can be used for preparing powdered inhalant, aerosols, sprays and oral mucosa doses.

Description

Astragaloside IV liposome and its pharmaceutical preparations technical field The invention belongs to the technical field of medicine and relates to a liposome pharmaceutical preparation, more specifically, an astragaloside IV liposome and a pharmaceutical preparation containing astragaloside IV liposome. Background technique Astragalus is one of the most commonly used traditional Chinese medicines with a long history and wide clinical application. Traditional Chinese medicine believes that astragalus is warm in nature and sweet in taste, and has the functions of invigorating qi and raising yang, solidifying the surface and antiperspirant, detoxifying and promoting muscle growth, reducing swelling and diuresis. Astragaloside IV is a monomeric compound extracted from the traditional Chinese medicine Astragalus membranaceus. In recent years, a large number of studies have shown that astragaloside IV can be used in the prevention and treatment of cardiovascular system diseas...

AI Technical Summary

Problems solved by technology

These problems include: 1. In order to prepare injections, the dissolution of astragaloside IV must be solved, so harmful cosolvents and surfactants are used for injection. 2. Patients with chronic heart failure have a long course of disease, and most of them do not need hospitalization. Long-term infusion will increase the patient's psychological burden and medical burden. 3. Intravenous infusion of drugs generally has a large input volume, which will increase the heart burden of heart failure patients and aggravate the degree of heart failure. There is a sense of fear in the pain of injection. If the medication cycle is long, this problem will become more prominent. 5. There are unsafe factors in the injection process, such as allergic reactions, pyrogen reactions, etc.

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