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Imaginal stem cell membrane stent in blood vessel, and its preparing method

A technology of adult stem cells and covered stents, applied in medical science, surgery, etc., can solve problems such as human injury, and achieve the effect of promoting re-endothelialization, non-immunogenicity, and beneficial to reconstruction

Inactive Publication Date: 2007-07-25
CHONGQING UNIV
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  • Abstract
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Problems solved by technology

[0005] The purpose of the present invention is to develop a new biofilm intravascular stent. In view of the current situation that the source of biofilm stent coating material is limited and the source route may cause certain damage to the human body, a porcine small intestinal submucosa intravascular stent and its preparation are proposed. The method provides a new source of biofilm material, and uses it as a carrier for the growth of adult stem cells to modify the endothelialization of the intravascular stent, promote the re-endothelialization process of the vascular injury after the implantation of the intravascular stent, and prevent the occurrence of ISR. occur

Method used

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  • Imaginal stem cell membrane stent in blood vessel, and its preparing method
  • Imaginal stem cell membrane stent in blood vessel, and its preparing method

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Embodiment Construction

[0031] Step 1: Preparation of SIS

[0032] 1. Physical treatment method: take the fresh pig small intestine within 4 hours of slaughter, remove the serosal layer and muscular layer of the small intestine with a knife handle wrapped in gauze, and rinse it with 40°C water continuously.

[0033] 2. The small intestine treated with physical methods was treated with a series of chemical methods at room temperature. The volume ratio of material to solution was kept at 1:100.

[0034] 1) Soak the SIS produced by the mechanical method in a solution containing 100mmol / L ethylenediaminetetraacetic acid (EDTA) and 10mmol / L NaOH (pH11-12) for 16h;

[0035] 2) Rinse the substrate with deionized water, soak in a solution containing 1mmol / L HCl and 1mmol / L NaCl (pH0~1) for 6~8h;

[0036] 3) Rinse the matrix with deionized water, and soak it in phosphate buffered solution (PBS) with 1mmol / L NaCl for 16h;

[0037] 4) After washing the matrix with deionized water, soak it in PBS solution (pH...

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Abstract

An adult stem cells covered internal vascular scaffold is composed of metallic internal vascular scaffold, SIS covering on said scaffold, and adult stem cells planted on SIS. Its preparing process includes such steps as preparing bioactive SIS, separating the endothelial archeocytes from human umbilical blood, planting the archeocytes, and covering on said internal vascular scaffold.

Description

technical field [0001] The invention relates to coating modification and endothelialization treatment of intravascular stents, and provides a new method for preventing restenosis in stents caused by intravascular stent implantation, and belongs to the technical field of biomedical devices. Background technique [0002] The introduction of intravascular stents into clinical practice is another major breakthrough in the field of coronary intervention since percutaneous transluminal coronary angioplasty (PTCA), because stents solve the problem of early vascular elastic recoil And 60% of the restenosis problems caused by the later negative remodeling process. Nevertheless, the long-term success of endovascular stents is limited by in-stent restenosis (ISR). Although stents can eliminate vascular elastic recoil and negative remodeling processes, stents can induce a more pronounced chronic vascular response than balloon angioplasty alone. About 20-30% of patients develop ISR, re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/16
Inventor 王贵学江涛
Owner CHONGQING UNIV
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