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Ophthalmic gel and its preparation method

An ophthalmic gel and matrix technology, which is applied in the field of traditional Chinese medicine ophthalmic gel and its preparation, can solve the problems of difficult to achieve auxiliary materials, weak eye irritation, etc., and achieves fast onset of action, strong bacteriostatic effect, and excellent biocompatibility. sexual effect

Active Publication Date: 2009-11-18
TEYI PHARMACEUTICAL GROUP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the eyes of the human body are weak in tolerance to external stimuli, and it is difficult for general excipients to meet the requirements of being used as a viscosity enhancer for the eyes.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Table 1

[0019]

[0020] As shown in Table 1: get bear bile powder, add 100g water for injection, heat and boil for 10 minutes to dissolve, let cool, add ethanol to make the alcohol content reach 75%, let stand for 24 hours, filter, and the filtrate reclaims ethanol; Borax, boric acid, sodium chloride, ethyl p-hydroxybenzoate, add 800g of water for injection, heat and boil to dissolve, filter, let cool, add sodium hyaluronate, soak, let stand for several hours, stir well, and recover ethanol The final medicinal solution is mixed, supplemented with water for injection to the specified amount, stirred evenly, and packaged.

Embodiment 2-4

[0022] Table 2

[0023] Element

[0024] As shown in Table 2: take bear bile powder, sodium chloride, ethyl p-hydroxybenzoate and add 100g water for injection, heat and boil for 10 minutes to dissolve, let cool, add ethanol to make the alcohol content reach 75%, let stand for 24 hours , filtered, and the filtrate recovered ethanol; take another 800g of water for injection, add sodium hyaluronate, soak it, let it stand for several hours, stir well, mix it with the medicinal solution after recovery of ethanol, add water for injection to the specified amount, stir well, divide Pack. The above process is carried out under sterile conditions.

Embodiment 5-7

[0026] table 3

[0027] Element

[0028] As shown in Table 3: Take sodium chloride, add about 80% water for injection, heat and boil to dissolve, filter, let cool, add sodium hyaluronate, soak, stand for several hours, and stir well. The borneol and benzyl alcohol are dissolved in an appropriate amount of ethanol, slowly stirred and added to the above-mentioned matrix, the pearl liquid is added to the mixture, water for injection is supplemented to a specified amount, stirred evenly, and packaged.

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PUM

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Abstract

The invention relates to an ophthalmic gel, which is composed of a matrix, active ingredients of traditional Chinese medicine, auxiliary materials and water, the matrix is ​​hyaluronic acid and / or sodium hyaluronate, and the ophthalmic gel is prepared by the following method: Add appropriate amount of water to the water-soluble excipients, heat to dissolve, and filter to obtain a clear liquid; add the matrix to the above clear liquid, soak, let it stand for several hours, and then stir evenly; add active ingredients of traditional Chinese medicine to the mixture obtained in the above steps to make up Water to a specific content, stirred evenly, and packaged to obtain finished products; wherein, the matrix, active ingredients of traditional Chinese medicine, auxiliary materials and water have the following mass ratios, matrix: active ingredients of traditional Chinese medicine: auxiliary materials: water=0.05~10.0:0.1~ 40.0: 1-14: 50-98; the active ingredient of the traditional Chinese medicine is one of the following components: bear bile or its extract, pearl or its extract, Zijinlong extract. The ophthalmic gel can increase the residence time of the medicine in the eye and reduce the loss of the medicine.

Description

technical field [0001] The invention relates to an ophthalmic medicine and a preparation method thereof, in particular to a traditional Chinese medicine ophthalmic gel and a preparation method thereof. Background technique [0002] Traditional Chinese medicine is the quintessence of our country. It has less toxic side effects and a wide variety of raw materials. It also has a long history of treating eye diseases and has many classic medicines. However, there are fewer varieties of traditional Chinese medicine ophthalmic preparations seen on the market in my country at present, and new varieties are even rarer. Compared with foreign capital and joint ventures in the research of western medicine, domestic manufacturers are far behind in the research, extraction and improvement of dosage forms of active ingredients of traditional Chinese medicine. At present, the preparation forms of Chinese patent medicines for treating eye diseases mainly include eye drops, eye drops, etc. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K47/36A61P27/02
Inventor 尚红鹰
Owner TEYI PHARMACEUTICAL GROUP CO LTD
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