Chitosan/starch blending medicine-carrying fibre, preparation method and use thereof

A technology of chitosan and chitosan solution, which is applied in the fields of fiber chemical characteristics, medical science, textiles and papermaking, etc., can solve the problems of unsatisfactory comprehensive properties of pure chitosan fibers, achieve excellent drug release properties, and be widely used. Foreground, the effect of improving performance

Active Publication Date: 2009-10-07
华山科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the overall performance of pure chitosan fiber is not ideal, and it cannot meet the requirements in some fields.

Method used

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  • Chitosan/starch blending medicine-carrying fibre, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1: The degree of deacetylation of 45g is 87%, and the viscosity-average molecular weight is 8.0×10 5 Chitosan is dissolved in 900ml of 2% (mass ratio) acetic acid solution to obtain chitosan solution; 5g of starch is dissolved in 100ml of distilled water to obtain starch solution. The above two solutions are fully mixed with 4g salicylic acid, filtered, and after degassing under reduced pressure, the aqueous solution of sodium tripolyphosphate (mass ratio) and absolute ethanol are mixed in a ratio of 4:6 to 6 to form 5% to 10%. The mixed liquid mixed in the ratio of :4 is a coagulation liquid, and the chitosan / starch drug-loaded fiber is prepared by solution spinning at room temperature, and the obtained fiber elongation rate is 20%. Its mechanical properties, water retention value and release performance are listed in Table 1.

Embodiment 2

[0011] Embodiment 2: Get 35g chitosan and dissolve in the acetic acid solution of 700ml 2% (mass ratio) to obtain chitosan solution; Get 15g starch and dissolve in 300ml distilled water to obtain starch solution. The above two solutions are fully mixed with 4g salicylic acid, filtered, and after degassing under reduced pressure, the aqueous solution of sodium tripolyphosphate (mass ratio) and absolute ethanol are mixed in a ratio of 4:6 to 6 to form 5% to 10%. The mixed liquid mixed in the ratio of :4 is a coagulation liquid, and the chitosan / starch drug-loaded fiber is prepared by solution spinning at room temperature, and the obtained fiber elongation rate is 20%. Its mechanical properties, water retention value and release performance are listed in Table 1.

Embodiment 3

[0012] Embodiment 3: Get 25g chitosan and dissolve in the acetic acid solution of 500ml 2% (mass ratio) to obtain chitosan solution; Get 25g starch and dissolve in 500ml distilled water to obtain starch solution. The above two solutions are fully mixed with 4g salicylic acid, filtered, and after degassing under reduced pressure, with the composition of 5% to 10% sodium tripolyphosphate (mass ratio) aqueous solution and absolute ethanol according to the ratio of 4: 6 to 6 The mixed liquid mixed in the ratio of :4 is a coagulation liquid, and the chitosan / starch drug-loaded fiber is prepared by solution spinning at room temperature, and the obtained fiber elongation rate is 20%. Its mechanical properties, water retention value and release performance are listed in Table 1.

[0013] The solution spinning method used in the above examples is a prior art, which has been described in detail in the existing literature, so the solution spinning method will not be repeated in each embo...

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Abstract

The invention discloses a chitosan / starch blend drug-loaded fiber with excellent mechanical properties, a preparation method and application thereof. The fiber is blended with chitosan, starch and salicylic acid as raw materials. The mass percentage of starch in the fiber is 10% to 65%, and the mass percentage of salicylic acid is 5% to 15%. The mass percentage of chitosan is 30% to 85%, and the fiber stretch rate is 10% to 30%. Its preparation method is to dissolve chitosan in acetic acid solution with a mass percentage of 1% to 2% to obtain a chitosan solution with a mass percentage of 3% to 5%, and dissolve starch in distilled water to obtain a mass percentage of 3% to 5%. 5% starch solution, according to the mass ratio of chitosan: starch: salicylic acid = 3 ~ 8.5: 1 ~ 6.5: 0.5 ~ 1.5, fully mix the above two solutions and salicylic acid, filter, decompress After defoaming, add coagulation solution, and obtain it by solution spinning method at room temperature. The chitosan / starch blended drug-loaded fiber can be widely used in medicine, textile and other fields, and is especially suitable for weaving non-woven fabrics as wound dressings.

Description

technical field [0001] The invention relates to a chitosan / starch blended drug-loaded fiber for making non-woven fabrics, a preparation method and application thereof, and belongs to the field of polymer materials. Background technique [0002] Chitosan is the second largest biological polysaccharide next to cellulose in nature, and it is also the only alkaline polysaccharide that exists in large quantities in nature. It has good biocompatibility, biodegradability, and excellent properties such as antibacterial, antiseptic, hemostasis and promotion of wound healing. In addition, the weak acid solution of chitosan is positively charged, so it can interact with negatively charged polymers such as DNA, antigens and most protein drugs, and is widely used in drug carriers and medical auxiliary materials. Chitosan also has good fiber-forming properties and is a good material for making non-woven fabrics. However, the comprehensive performance of pure chitosan fiber is not ideal,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01F8/18A61L15/28
Inventor 杜予民王群胡先文
Owner 华山科技股份有限公司
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