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Preparing process for Chinese medicine for treating vocal nodules and polyp of vocal cord and its use

A technology for vocal cord polyps and vocal cord nodules, applied to medical preparations containing active ingredients, pharmaceutical formulas, drug combinations, etc., can solve the problems of high loss, labor-intensive, time-consuming, etc., achieve tissue proliferation inhibition, reduce whole blood viscosity, The effect of improving the utilization rate

Active Publication Date: 2009-09-23
XIAN BEILIN PHARMA
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0004] CN1544077A discloses a kind of " Chinese medicine for the treatment of chronic and dull throat symptoms ", and its tablet, capsule preparation process loses more in the process of raw material concentration, and the concentrated extract density is unfavorable for mixing, is not easy to dry, takes a lot of work, Time-consuming, and the utilization rate of raw materials and the extraction rate of active ingredients are not high

Method used

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  • Preparing process for Chinese medicine for treating vocal nodules and polyp of vocal cord and its use
  • Preparing process for Chinese medicine for treating vocal nodules and polyp of vocal cord and its use
  • Preparing process for Chinese medicine for treating vocal nodules and polyp of vocal cord and its use

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0011] Experimental example 1 Water extraction process optimization

[0012] According to the analysis of the factors affecting the water extraction process, the main factors are the amount of water added, the time of decoction, and the number of times of decoction. The orthogonal test method is used to investigate the index of the dry paste amount and the transfer rate of chlorogenic acid, and the best is selected Process conditions.

[0013] 1. Investigation of water absorption of medicinal materials:

[0014] According to the above prescription ratio, weigh 149.3g of water-extracted medicinal materials, add 10 times the amount of water to soak until thoroughly, filtered, and the measured average water absorption rate is 208%.

[0015] 2. Orthogonal experimental design

[0016] After analyzing and comparing factors such as extraction times, extraction time, water addition and other factors involved in the extraction process, each design has 3 levels. The design factor level tabl...

experiment example 2

[0040] Experimental example 2 Optimization of alcohol precipitation process

[0041] 1. Selection of alcohol precipitation conditions

[0042] The water extracts of medicinal materials are easy to absorb moisture and have large impurities. Therefore, during the preparation process, they should be treated with alcohol to retain the active ingredients, remove impurities, and reduce the dosage. Therefore, the different concentrations of alcohol precipitated The total amount of paste and the content of chlorogenic acid were investigated. The decoction containing starch and mucilage is purified by alcohol precipitation. After analyzing the influencing factors of alcohol precipitation, select the concentration of alcohol precipitation (A), the relative density of the drug solution (B), and the standing time (C), and design an orthogonal test according to L9(3)4 to determine the amount of dry paste and chloroform The acid transfer rate is used as an evaluation index for comprehensive ana...

experiment example 3

[0054] Experimental example 3 Water extraction and alcohol precipitation process and water extraction process optimization

[0055] According to the parameters determined by the water extraction process and the water extraction and alcohol precipitation process, the pilot production was carried out according to 10 times the amount of the prescription, and the formed particles were investigated to compare the similarities and differences between the two processes.

[0056] 1. Comparison of test results of three batches of pilot products

[0057] The test results of three batches of pilot products are shown in Table 8.

[0058] Table 8 Test results of three batches of pilot products with different processes

[0059]

[0060] *A is water extraction process, B is water extraction and alcohol precipitation process

[0061] It can be seen from the above table that the amount of extract extracted by the water extraction process and the amount of dry paste are large, the difference betw...

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Abstract

The present invention relates to Chinese medicine preparation, and is especially the preparation process and application of Chinese medicine preparation for treating vocal nodules and polyp of vocal cord. The preparation process of the present invention is stable, practical, high material utilizing rate and high effective component extracting rate, and the Chinese medicine preparation has high chlorogenic acid content. The Chinese medicine preparation has the functions of promoting blood circulation to disperse blood clots, lowering blood viscosity, lowering fibrinogen content and platelet adhesiveness, and inhibiting proliferation of granulation tissue.

Description

Technical field: [0001] The invention relates to a preparation process and application of a traditional Chinese medicine preparation, in particular to a preparation process and application of a traditional Chinese medicine for treating vocal cord nodules and vocal cord polyp symptoms. Background technique: [0002] Throat disease is a common clinical disease and frequently-occurring disease. The incidence rate has been increasing nationwide in recent years. At present, the number of patients with throat disease in my country is increasing. According to relevant clinical reports, patients with various acute and chronic throat diseases are domestic About 12% of the total number of people, the high incidence rate will arouse the attention of the medical profession and the people. [0003] At present, there are few pure Chinese medicines for the treatment of throat diseases in China, especially for the treatment of chronic throat (vocal cord nodules, vocal cord polyps, vocal cord muc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K35/38A61K35/56A61K9/00A61P11/04A61K35/57A61K35/64
Inventor 黄小华付彬
Owner XIAN BEILIN PHARMA
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