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Composite vegetable drug for treating type II diabetes and increasing insulin sensitivity, extracts and extraction method

A technology for insulin sensitization and botanical medicine, which is applied to the extraction of combined botanical medicine extracts, the field of combined botanical medicines and their extracts for the treatment of type II diabetes and insulin sensitization, and can solve the problem that the mechanism research has not been carried out and in-depth and lacks. Insulin resistance and other problems, to achieve the effect of low cost, lower random blood sugar, and less side effects

Active Publication Date: 2009-09-23
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the current research is limited to the observation of improving IR, and the mechanism research has not been carried out and in-depth, especially the molecular biological mechanism of IR has not been involved. At present, there is still a lack of effective traditional Chinese medicine preparations for treating insulin resistance in clinical practice.

Method used

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  • Composite vegetable drug for treating type II diabetes and increasing insulin sensitivity, extracts and extraction method
  • Composite vegetable drug for treating type II diabetes and increasing insulin sensitivity, extracts and extraction method
  • Composite vegetable drug for treating type II diabetes and increasing insulin sensitivity, extracts and extraction method

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Embodiment 1

[0032] Embodiment 1. The present embodiment is a combination herbal medicine for treating type II diabetes and insulin sensitivity and its extract and its extraction method. The weight (gram) formula of the combined herbal medicine extract raw material is: Cortex Moutan 1710, Ze Xie 1026, Polygonum multiflorum 1026, Polygonatum 1539, Anemarrhena 1026, Coptis 342;

[0033] (a) Add 60% ethanol with 7 times the amount of medicinal materials to Coptidis Rhizome, heat and reflux extraction for 3 times, each time for 1.8 hours, combine the extracts, recover ethanol under reduced pressure, and concentrate to a clear paste with a relative density of 1.25 at 50°C to obtain Coptidis Rhizome extract Coptis chinensis ointment;

[0034](b) Cortex Moutan adds 6% sodium chloride NaCl aqueous solution of 4 times of medicinal material amount, soaks after 6 hours, distills, collects the initial distillation liquid 3.5 times of medicinal material amount and preserves in another device; Continue ...

Embodiment 2

[0036] Embodiment 2. The present embodiment is a combination herbal medicine for treating type II diabetes and insulin sensitization and its extract and its extraction method. The weight (gram) formula of the combined herbal medicine extract raw material is: Cortex Moutan 1710, Ze Xie 1026, Polygonum multiflorum 1026, Polygonatum 1539, Anemarrhena 1026, Coptis 342;

[0037] (a) Add 60% ethanol with 7 times the amount of medicinal materials to Coptidis Rhizoma, heat and reflux extraction for 3 times, each time for 1.8 hours, combine the extracts, recover ethanol under reduced pressure, and concentrate to a clear paste with a relative density of 1.25 at 50°C to obtain Coptidis Rhizome extract Coptis chinensis ointment;

[0038] (b) Cortex Moutan adds 6% sodium chloride NaCl aqueous solution of 4 times of medicinal material amount, soaks after 6 hours, distills, collects the initial distillation liquid 3.5 times of medicinal material amount and preserves in another device; Contin...

Embodiment 3

[0040] Embodiment 3, the present embodiment is a kind of combined herbal medicine for treating type II diabetes and insulin sensitization and its extract and its extraction method. Xie 1231, Polygonum multiflorum 821, Polygonatum 1847, Anemarrhena 821, Coptis 274;

[0041] (a) Add 70% ethanol that is 5 times the amount of medicinal materials to Coptidis Rhizoma, heat and reflux for extraction 4 times, each time for 1.5 hours, combine the extracts, recover ethanol under reduced pressure, and concentrate to a clear paste with a relative density of 1.05 at 50°C to obtain Coptidis Rhizome extract Coptis chinensis ointment;

[0042] (b) Cortex Moutan adds 7% sodium chloride NaCl aqueous solution of 3 times the amount of medicinal material, soaks for 4.5 hours, distills, collects 3 times the amount of medicinal material of the first distillate and saves it in another device; continue distilling until the distillate does not show milky white, and the medicinal The slag and residual ...

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Abstract

A combined plant medicine for treating type II diabetes and insulin sensitivity, its extract and its extraction method. It is made from the following raw materials: Cortex Moutan, Alisma, Radix Polygoni Multiflori, Polygonatum, Anemarrhena, Coptidis. Coptis chinensis is extracted with ethanol under reflux, ethanol is recovered, and concentrated to obtain Coptis chinensis ointment; Moutan cortex is infiltrated with sodium chloride solution, steam distilled, left standing, and the crystals are collected and dried to obtain paeonol from Moutan cortex extract; Moutan cortex dregs and Zhimu , Alisma, Polygonum Polygoni Multiflori, and Polygonatum Polygonatum were extracted with ethanol under reflux, recovered ethanol, concentrated, combined with Coptis chinensis paste, mixed, dried, crushed into fine powder, added paeonol, and obtained the extract. The invention has the functions of nourishing kidney and liver, clearing heat and resolving phlegm, can treat type 2 diabetes and improve insulin resistance, is safe and effective, has little side effects, and has definite curative effect on treating type 2 diabetes and improving insulin resistance.

Description

technical field [0001] The present invention relates to combined herbal medicine and its extract, especially the combined herbal medicine and its extract for treating type II diabetes and insulin sensitivity; the invention also relates to the extraction method of the combined herbal medicine extract. Background technique [0002] Diabetes is a common clinical endocrine and metabolic disease. With the improvement of living standards and changes in lifestyle, the incidence of diabetes has increased year by year. In my country, the incidence has reached 3%, of which more than 90% are type 2 diabetes. Research on its prevention and treatment It is listed as one of the main tasks of the medical profession today. Both at home and abroad are constantly exploring new mechanisms of diabetes pathogenesis and new ways of treatment. Insulin resistance (Insulin resistance, IR) is a prominent feature of type 2 diabetes. Insulin resistance is an important factor in the occurrence and devel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61K36/8964A61K36/884A61K36/718A61K36/71A61K36/704A61K9/00A61P3/10A61P5/50
Inventor 蔡宝昌潘扬章晨峰曹亮
Owner JIANGSU KANION PHARMA CO LTD
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