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Preparation method of breviscapine raw material medicine by using big-hole resin

A macroporous resin, breviscapine technology, which is applied in the directions of sugar derivatives, ion exchange regeneration, ion exchange, etc., can solve problems such as not being well solved, and achieves the problem of solving refining problems, simple process steps, and easy industrial production. Effect

Active Publication Date: 2009-02-04
KUNMING LONGJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The refining method of scutellarin raw material medicine has not been solved well, so it is necessary to study a new refining method to make it meet the requirements of the "Drug Standards" issued by the Ministry

Method used

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  • Preparation method of breviscapine raw material medicine by using big-hole resin
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  • Preparation method of breviscapine raw material medicine by using big-hole resin

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Weigh 500g of scutellarin raw material with a scutellarin B content of 84.69%, add boiling water to prepare a concentration of 20% by weight, adjust the pH value to 7.5 with 20% sodium bicarbonate, and dissolve it. The filtrate is first passed through a 16000rpm continuous tube After centrifugation in a test centrifuge, filter again, add the filtrate to the D101 macroporous resin column, use water as the eluent, and collect the eluate until it is basically colorless. Use 20% hydrochloric acid to adjust the pH value of the eluent to 1, let it settle for 10 hours, filter, wash the precipitate with water until neutral (use AgNO3 to check for no Cl-), dry it at 105°C, send it for inspection, and pass through the HPLC layer According to the analysis and analysis, the content of breviscapine raw material medicine is increased from 84.69% to 91.65% from the original B content, which meets the requirements of "Drug Standards" breviscapine injection (1998) issued by the Ministry....

Embodiment 2

[0068] Weigh 500g of scutellarin raw material with a scutellarin B content of 78.99%, add boiling water to prepare a concentration of 10% by weight, adjust the pH value to 7.5 with 5% sodium hydroxide solution, and dissolve the filtrate at 16000rpm After centrifugation in a continuous tube test centrifuge, filter again, add the filtrate to the AB-8 macroporous resin column, use water as the eluent, and collect the eluate until it is basically colorless. The eluate was adjusted to pH 1 with 15% sulfuric acid solution, allowed to settle for 10 hours, filtered, and the precipitate was washed with water until neutral (use AgNO3 to check for the absence of Cl-). All operations are repeated 1 time. Dried at 80°C, sent for inspection, and analyzed by high performance liquid chromatography, the content of breviscapine raw material drug increased from 78.99% to 91.99%, which complied with the "Drug Standard" issued by the Ministry of Breviscapine Injection (1998 )Regulation.

[0069]...

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Abstract

The invention relates to a method for refining the breviscapinun original material medicine with a large-hole resin, especially an original material medicine of scutellar content of 90-95%. The inventive method is composed of following steps: firstly adopting a large-hole resin of a type D101 or AB-8, with a weight ratio of large-hole resin dosage and original material medicine 10-15:1, having the water as solvent to fill column; secondly, the preparation of the breviscapinun filling solution: choosing the breviscapinun as material with a scutellar content of 75-85%, preparing into a solution with a weight percent concentration of 10-20% with boiling water; adjusting the pH to 7.0-7.5 with lye, filtering, getting the column filling solution; thirdly, adding the column filling solution of the step 2 to the large-hole resin of the step 1, eluting the eluant by water, collecting the eluant until the eluant is substantial transparent; fourthly, adjusting the collected eluant pH value in the third step to 1-2, precipitating yellow deposit, stewing more than 5 hours, filtering, washing the deposit to the neutral, testing no Cl-; fifthly, drying the deposit.

Description

technical field [0001] The invention relates to a method for refining a scutellarin raw material drug with a macroporous resin, in particular to a method for preparing a raw material drug with a scutellarin B content of 90-95%. Background technique [0002] Breviscapus is a flavonoid component isolated from the whole herb of Erigeron breviscapus (Vant) Hand-Mazz. According to the "Drug Standards" issued by the Ministry, the content of breviscapus in breviscapus injection should be more than 90%. . Because the current method of refining breviscapine raw material medicine is a refining method of imitating huangling glycosides, the product quality cannot meet the requirements of the standards issued by the Ministry. The refining method of scutellarin raw material medicine has not been solved well, so it is necessary to study a new refining method to make it meet the requirements of the "Drug Standards" issued by the Ministry. [0003] Chinese Patent Application No. 00113019.6...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/07B01D15/08
Inventor 张人伟程惠佳樊献俄
Owner KUNMING LONGJIN PHARMA
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