Post-surgery functional barrier film and method for preparing the same
An isolation membrane and functional technology, which is applied in the field of biodegradable polymer anti-adhesion membranes, can solve the problems of not taking into account the reduction of tissue fluid penetration and tissue healing, the inability to achieve the time release of various drugs, and the unsatisfactory anti-adhesion effect. Achieve the effect of preventing peridural fibrosis and adhesion, reducing tissue fluid infiltration, and reducing organ infection
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Embodiment 1
[0023] Add 10 grams of poly D with a molecular weight of 400,000, L-lactic acid and 0.2 grams of cortisone into 100 ml of ethyl acetate, fully dissolve and mix well, then pour it into a flat container to form a film, and make the ethyl acetate fully volatilize to form a thick film. It is a 0.04 mm film, cut into 4×6 (mm), 10×20 (mm) and 50×80 (mm) sheets, and after disinfection and sterilization, it is vacuum-sealed and protected from light for future use.
Embodiment 2
[0025] Take 10 grams of D, L-lactic acid, glycolic acid and caprolactone copolymer with a molecular weight of 150,000 and add it to 100 ml of acetone. After fully dissolving, add 0.15 g of gentamicin and 0.15 g of dexamethasone, mix well, and pour into Form a film in a flat container, make acetone fully volatilize to make a film with a thickness of 0.08 mm, cut into 4×6 (mm), 10×20 (mm) and 50×80 (mm) sheets, and disinfect and sterilize After processing, vacuum seal and store away from light for later use.
Embodiment 3
[0027] Take 5 grams of poly D with a molecular weight of 350,000, add 50 ml of ethyl acetate to L-lactic acid, add 0.15 g of hydrocortisone after fully dissolving, mix well, pour it into a flat container to form a film, and make the ethyl acetate fully volatilize An upper layer film having a thickness of 0.03 mm was prepared. Take 3 grams of D, L-lactic acid and glycolic acid copolymer with a molecular weight of 150,000, add 50 milliliters of ethyl acetate, add 0.15 grams of nifedipine after fully dissolving, mix well, pour it into a flat container to form a film, and make ethyl acetate The ester is fully volatilized to form a middle layer film with a thickness of 0.02 mm. Take 2 grams of poly D with a molecular weight of 50,000, L-lactic acid and polyethylene glycol copolymer and add it to 20 milliliters of acetone. After fully dissolving, add 0.15 grams of kanamycin, mix well, and pour it into a flat container to form a film. The acetone is fully volatilized to form a botto...
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