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Vitamin C crystallization process seed crystal production method

A vitamin and seed crystal technology, applied in solution crystallization, organic chemistry, etc., can solve the problems of large difference in grain size, difficult to control the number of grains, crystal plane damage, etc. Easy-to-control, even-sized effects

Inactive Publication Date: 2008-07-09
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] So far, the seed crystals required in the production process of vitamin C are generally obtained by grinding the crude product of vitamins with a ball mill. Although the seed crystals made by a ball mill have the advantages of convenient operation, they have many disadvantages. One is that the power consumption is large, and the grain size varies greatly, ranging from 1 μm to 80 μm, which is extremely uneven, and the number of grains is difficult to control. The surface is uneven, forming many potholes, and the seeds are easy to contain impurities and pigments during growth, which affects the quality of vitamin C
Therefore, it is not ideal to use vitamin C powder ground by a ball mill as a seed crystal.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Put 100 parts of vitamin C powder and 50 parts of water in a stirring pot, heat to 60°C, stir and dissolve to form a supersaturated solution, put it into a U-shaped crystallization tank with stirring and ultrasonic waves, and add 25 parts 95% concentration of ethanol, the stirring speed is 50rpm, the ultrasonic frequency is 25KHz, and the time is 1 minute; after the stirring stops, add 25 parts of 95% concentration of ethanol, restart the stirring and ultrasonic wave, the time is 2 minutes; stand still for 30 minutes Obtain seed crystals with a size of 25-35 μm and a suspension density of 200,000-400,000 / mm 3 .

Embodiment 2

[0015] Put 100 parts of vitamin C powder and 55 parts of water in a stirring pot, heat to 65°C, stir and dissolve to form a supersaturated solution, put it into a U-shaped crystallization tank with stirring and ultrasonic waves, and add 50 parts 95% concentration of methanol, the stirring speed is 60rpm, the ultrasonic frequency is 20KHz, and the time is 10 minutes; after the stirring stops, add 50 parts of 95% concentration of methanol, restart the stirring and ultrasonic wave, the time is 10 minutes; stand still for 60 minutes Obtain seed crystals with a size of 25-35 μm and a suspension density of 200,000-400,000 / mm 3 .

Embodiment 3

[0017] Put 100 parts of vitamin C powder and 60 parts of water in a pot with stirring, heat to 70°C, stir and dissolve to form a supersaturated solution, put it into a U-shaped crystallization tank with stirring and ultrasonic waves, add 30 parts 95% concentration of ethanol, the stirring speed is 70rpm, the ultrasonic frequency is 35KHz, and the time is 5 minutes; after the stirring stops, add 30 parts of 99.9% concentration of ethanol, restart the stirring and ultrasonic wave, the time is 5 minutes; stand still for 40 minutes Obtain 15-25μm seed crystal paste with a suspension density of 50-700,000 / mm 3 , the seed crystal grains are uniform and the crystal plane is complete.

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PUM

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Abstract

The present invention discloses the process of preparing crystal seed for vitamin C crystallization. The process includes heating vitamin C powder in 100 weight portions and water in 50-60 weight portions inside one pot at 60-70 deg.c via stirring to form over saturated solution; setting inside U-shaped stirring ultrasonic crystallizer, adding 95-99.9 % concentration methanol or ethanol in 25-50 weight portions, stirring at 50-70 rpm and applying ultrasonic wave at 20-35 KHz frequency for 1-10 min, adding other 25-50 weight portions of 95-99.9 % concentration methanol or ethanol before further stirring and ultrasonic action for 2-10 min, and letting stand for 30-60 min to obtain crystal seed with homogeneous crystal grains and complete crystal face. The present invention has fast crystal nucleus forming speed.

Description

technical field [0001] The invention belongs to the field of vitamin C preparation, and in particular relates to a seed crystal seed production method in the crystallization process of vitamin C. Background technique [0002] So far, the seed crystals required in the production process of vitamin C are generally obtained by grinding the crude product of vitamins with a ball mill. Although the seed crystals made by a ball mill have the advantages of convenient operation, they have many disadvantages. One is that the power consumption is large, and the grain size varies greatly, ranging from 1 μm to 80 μm, which is extremely uneven, and the number of grains is difficult to control. The surface is uneven, forming many potholes, and the seeds are easy to contain impurities and pigments during growth, which affects the quality of vitamin C. Therefore, it is not ideal to use the vitamin C powder ground out by a ball mill as a seed crystal. Contents of the invention [0003] Th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D307/62B01D9/02
Inventor 李国基耿予欢于淑娟
Owner SOUTH CHINA UNIV OF TECH
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