Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Beta-cyclodextrin / amoxicillin inclusion compound and its composition with clavulanic kalium and preparation method thereof

A technology of potassium clavulanate and amoxicillin, applied in the field of preparation of pharmaceutical compositions

Inactive Publication Date: 2008-06-04
NANJING J ONE MEDICAL TECH DEV
View PDF3 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, amoxicillin and its compound preparations with potassium clavulanate have not yet been reported using β-cyclodextrin for molecular inclusion supramolecular technology preparations

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1, mix 100 ml of pure water with 100 g of β-cyclodextrin, add 33 g of amoxicillin at room temperature at 20°C, grind thoroughly for 8 hours, then place at 5°C for 12 hours; filter, and wash the solid with water 2 times. Vacuum-dry at 40°C for 12 hours to obtain a white solid clathrate. The solid clathrate is crushed through a 100-mesh sieve, mixed with 2.36 grams of potassium clavulanate, passed through an 80-mesh sieve twice, dry-granulated, and ground into a powder to obtain a pharmaceutical composition. In the composition, amoxicillin-clavulanate potassium The dose ratio is 14:1.

Embodiment 2

[0055] Embodiment 2: substantially the same as embodiment 1, but add 200 milliliters of pure water, fully grind for 5 hours.

Embodiment 3

[0056] Embodiment 3: substantially the same as embodiment 1, but add 20 grams of amoxicillin. The obtained white solid clathrate was mixed with 1.4 g of potassium clavulanate to prepare a powdery pharmaceutical composition.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a beta-cyclodextrin / amoxicillin inclusion compound medicinal composition which comprises amoxicillin and beta cyclodextrin by the weight ratio of 1:2.5-1:5. In a preferred embodiment, the composition also comprises clavulanate potassium, wherein the mass ratio of amoxicillin and clavulanate potassium is 14:1-2:1, the supplementary materials are selected from crystalline cellulose, maize starch, citric acid, talcum powder, sodium carboxymethylstarch, stearic acid, calcium stearate, magnesium stearate, amylopectin, lactose, mannitol, crosslinked povidone, talcum powder, polyethylene glycol 4000, and low substituted methylcellulose propylene glycol ether. The invention also discloses the preparing process.

Description

technical field [0001] The invention relates to a pharmaceutical composition composed of beta-cyclodextrin inclusion amoxicillin and potassium clavulanate, and a preparation method of the pharmaceutical composition. Background technique [0002] The β-lactam antibiotic amoxicillin / clavulanate potassium compound preparation was originally researched and developed by the world-renowned GlaxoSmithKline pharmaceutical company, and was approved by the FDA on August 6, 1984. So far, this product has maintained its status as the world's best-selling drug for 13 consecutive years, ranking first in the world's anti-infective drugs. This product has been recorded in Chinese Pharmacopoeia. [0003] Amoxicillin combined with clavulanic acid can inhibit staphylococcus, Haemophilus influenzae, catarrhalis, Escherichia coli, Klebsiella, Proteus mirabilis, Proteus vulgaris, Neisseria gonorrhoeae, Legionella, Bacteroides fragilis, etc. The β-lactamase produced by microorganisms destroys am...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/43A61K31/424A61K47/40A61P31/04
Inventor 任勇陆亚鹏王亚娜
Owner NANJING J ONE MEDICAL TECH DEV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com