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64 results about "PAR-1 Antagonists" patented technology
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Vorapaxar (SCH 530348) and atopaxar (E5555) are oral protease-activated receptor-1 (PAR-1) antagonists with high bioavailability. They inhibits thrombin induced platelet aggregation by competitively inhibiting PAR-1.
"The Use of a PAR-1 Antagonist in Combination with a P2Y12 ADP Receptor Antagonist for Inhibition of Thrombosis"
The treatment and prevention of thrombotic events are provided through co-administration of PAR-1 and the P2Y12 ADP receptor antagonists. Combined inhibition of the PAR-1 and the P2Y12 ADP platelet activation pathways had synergistic antithrombotic and antiplatelet effects, as demonstrated in co-administration of SCH 602539 and cangrelor.
Owner:MERCK SHARP & DOHME CORP
A class of oxadiazole sulfoxide compounds containing halogenated benzene, its preparation method and use
ActiveCN104529927BGood antithrombotic activityOrganic active ingredientsOrganic chemistryBenzeneHalogen
The invention relates to the field of drugs associated with thrombotic diseases, in particular to a category of PAR-1 antagonists of an oxadiazole sulfoxide structure comprising halogeno benzene, a preparation method of the PAR-1 antagonists, and application of drug combinations comprising the halogeno benzene and the halogeno benzene in preparation of the drugs for treating the thrombotic diseases. Please see the formula in the specification, wherein R is selected from halogen substituent groups.
Owner:邳州德好农产品加工有限公司
Compound with aniline and diene fluoro adamantane structure and preparation method and application thereof
ActiveCN104529859AGood antithrombotic activityOrganic active ingredientsOrganic chemistryAnilinePar 1 antagonist
The invention relates to the field of drugs relevant to thrombotic diseases, in particular to a PAR-1 antagonist with an aniline and diene fluoro adamantane structure, a preparation method of the PAR-1 antagonist and the application of the PAR-1 antagonist. The structural general formula of the PAR-1 antagonist is specified in the specification, wherein R1 and R2 are selected from alkyl groups of H and C1-C5 respectively.
Owner:邳州市润宏实业有限公司
Local Delivery of PAR-1 Antagonists to Treat Vascular Complications
Described herein are methods and medical devices used to deliver bioactive agents locally to patients in need of treatment and / or prevention of cardiovascular conditions Local delivery of protease-activated receptor 1 (PAR-1) antagonists are described herein from implantable medical devices including, but not limited to, stents.
Owner:MEDTRONIC VASCULAR INC
Exocyclic imine compound containing benzo five-membered heterocycle, preparation method and application of exocyclic imine compound
ActiveCN102757396AGood antithrombotic activityOrganic active ingredientsOrganic chemistryBenzeneProteinase activity
The invention relates to the field of medicines relevant to thrombotic diseases, in particular to a PAR (protease activated acceptor)-1 antagonist with an exocyclic imine structure containing benzo five-membered heterocycle, a preparation method of the PAR-1 antagonist, a medicine composition containing the PAR-1 antagonist and application of the PAR-1 antagonist to medicines for treating the thrombotic diseases. R1, R2 and R3 are independently selected from alkyl groups of C1, C2, C3, C4 and C5, and X is selected from O and C(CH3)2.
Owner:TIANJIN INSTITUTE OF PHARMA RESEARCH
PAR-1 Antagonists for Use in the Treatment or Prevention of Influenza Virus Type A Infections
InactiveUS20120213802A1Inhibition of replicationBiocideOrganic active ingredientsPar1 antagonistAgonist
Owner:INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
PAR-1 antagonists for use in the treatment or prevention of influenza virus type A infections
Owner:INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
A trans-cyclohexane amide compound and its application
The invention relates to the field of medicines related to thrombotic diseases and in particular relates to PAR-1 (protease activated receptors-1) antagonists containing trans-cyclohexane amide structures shown in a formula (I) and an application of the PAR-1 antagonists to preparation of medicines for treating thrombotic diseases.
Owner:ZHEJIANG PHARMA COLLEGE
Nitrile-grouping benzene diene tetrazole compound and preparation method and application thereof
ActiveCN104496922AGood antithrombotic activityOrganic chemistryBlood disorderPar 1 antagonistAntagonist
The invention relates to the field of medicine correlated to thrombotic diseases, in particular to a PAR-1 antagonist with a nitrile-grouping benzene diene tetrazole structure and a preparation method and application of the antagonist. As shown in the description, R1 represents an alkyl group of H, C1-C3 and a naphthenic base of C3-C5.
Owner:HONGGUAN BIO PHARMA CO LTD
Halogenated phenyl-containing trans-cyclohexane amide compound and application thereof
InactiveCN104356093AGood antithrombotic activityOrganic chemistryBlood disorderHalogenPar 1 antagonist
The invention relates to the field of thrombotic disease related medicines. Specifically, the invention relates to a trans-cyclohexane amide structured PAR-1 antagonist containing structures, such as halogenated phenyl and the like, a preparation method of the antagonist and application of the antagonist in preparation of medicines for treating thrombotic diseases, wherein R is selected from C1-C3 alkyl, C3-C5 cycloalkyl and halogen substituent.
Owner:ZHEJIANG PHARMA COLLEGE
A compound containing nitrobenzene and diene adamantane structure, its preparation method and application
ActiveCN104447482BGood antithrombotic activityOrganic active ingredientsOrganic chemistryNitrobenzenePar 1 antagonist
The invention relates to the field of medicine related to thrombotic diseases, in particular to a PAR-1 antagonist shown in the specification and containing a nitrobenzene and diene adamantine structure and a preparation method and application of the PAR-1 antagonist.
Owner:HONGGUAN BIO PHARMA CO LTD
Halogenated pyridyl containing trans-cyclohexane amide compound and application thereof
InactiveCN104356059AGood antithrombotic activityOrganic chemistryBlood disorderPar 1 antagonistMedicinal chemistry
The invention relates to the field of thrombotic disease related medicines. Specifically, the invention relates to a trans-cyclohexane amide structured PAR-1 antagonist containing structures, such as halogenated pyridyl and the like, a preparation method of the antagonist and application of the antagonist in preparation of medicines for treating thrombotic diseases, wherein R is selected from C1-C3 alkyl and F, Cl, Br and I substituent.
Owner:ZHEJIANG PHARMA COLLEGE
Compound containing alcoxyl phenyl group and diene adamantane structure and preparation method and application thereof
ActiveCN104447484AGood antithrombotic activityOrganic active ingredientsOrganic chemistryPhenyl groupPar 1 antagonist
The invention relates to the field of medicine relevant to thrombotic diseases, in particular to a PAR-1 antagonist containing an alcoxyl phenyl group and a diene adamantane structure and a preparation method and application of the PAR-1 antagonist. According to the general formula (please see the specification), R is selected from an alkyl group of H, an alkyl group of C1-C5 and an alkyl group of C3-C8.
Owner:HONGGUAN BIO PHARMA CO LTD
One category of oxadiazole sulfoxide compounds comprising alcoxyl p-substituted benzene, and preparation method and application thereof
ActiveCN104529931AGood antithrombotic activityOrganic active ingredientsOrganic chemistryBenzeneAlkoxy group
The invention relates to the field of drugs associated with thrombotic diseases, in particular to a category of PAR-1 antagonists of an oxadiazole sulfoxide structure comprising alkoxy p-substituted benzene, a preparation method of the PAR-1 antagonists, and application of drug combinations comprising the alkoxy p-substituted benzene and the alkoxy p-substituted benzene in preparation of the drugs for treating the thrombotic diseases. Please see the formula in the specification, wherein R1 and R2 are defined according to the description in the specification.
Owner:肇庆市科至自动化设备有限公司
Compound containing aniline and diene adamantane structure and preparation method and application thereof
ActiveCN104447483AGood antithrombotic activityOrganic active ingredientsOrganic chemistryAnilinePar 1 antagonist
The invention relates to the field of medicine relevant to thrombotic diseases, in particular to a PAR-1 antagonist containing an anilino group and a diene adamantane structure and a preparation method and application of the PAR-1 antagonist. According to the general formula (please see the specification), R<1> and R<2> are selected from an alkyl group of H and an alkyl group of C1-C5 respectively.
Owner:HONGGUAN BIO PHARMA CO LTD
Halogenated phenyldiene tetrazole compound, its preparation method and use
ActiveCN104496924BGood antithrombotic activityOrganic chemistryBlood disorderHalogenPar 1 antagonist
The invention relates to the field of medicine correlated to thrombotic diseases, in particular to a PAR-1 antagonist with a halobenzene diene tetrazole structure and a preparation method and application thereof. As shown in the description, R1 represents an alkyl group of H, C1-C3 and a naphthenic base of C3-C5, and R2 represents a halogen substituted base.
Owner:铜陵易难信息科技有限公司
Oxadiazole sulfoxide compound containing amino substituted benzene and preparation method and purposes thereof
The invention relates to the field of medicines related with thrombotic diseases, in particular to PAR-1 antagonists which contain the amino substituted benzene and are of an oxadiazole sulfoxide structure, a preparation method thereof, medicine combinations containing the PAR-1 antagonists and applications of the PAR-1 antagonists in preparing medicines for treating thrombotic diseases. The formula is as follows, wherein the definition of R is as described in the specification.
Owner:FOSHAN SAIWEISI MEDICINE SCI & TECH
Trans-cyclohexane amides containing nitrile phenyl groups and uses thereof
Owner:ZHEJIANG PHARMA COLLEGE
A class of compounds containing alkoxyphenyl and diene fluoroadamantane structures and uses thereof
ActiveCN104478782BGood antithrombotic activityOrganic active ingredientsOrganic chemistryPhenyl groupPar 1 antagonist
The invention relates to the field of medicine related to the thrombotic diseases, in particular to a class of PAR-1 antagonist containing an alcoxyl phenyl group and diene fluoro adamantane structure and a preparation method and application of the class of PAR-1 antagonist containing the alcoxyl phenyl group and diene fluoro adamantane structure. Please see the formula in the specification, wherein the R is selected from the H alkyl group or C1-C5 alkyl group and the C3-C8 naphthenic base.
Owner:邳州市润宏实业有限公司
Alkoxy phenyl substituted trans-cyclohexane amide compound and application thereof
InactiveCN104356095AGood antithrombotic activityOrganic chemistryBlood disorderPar 1 antagonistMedicinal chemistry
The invention relates to the field of thrombotic disease related medicines. Specifically, the invention relates to a terminal alkoxy phenyl substituted trans-cyclohexane amide structured PAR-1 antagonist, a preparation method thereof and application of the antagonist in preparation of medicines for treating thrombotic diseases, wherein R is selected from C1-C3 alkyl and C3-C5 cycloalkyl.
Owner:ZHEJIANG PHARMA COLLEGE
Trans-cyclohexane amide compound and preparation method and medicinal application thereof
InactiveCN104356094AGood antithrombotic activityOrganic chemistryBlood disorderMedicinePar 1 antagonist
The invention relates to the field of thrombotic disease related medicines. Specifically, the invention relates to a trans-cyclohexane amide structure containing PAR-1 antagonist, a preparation method thereof and application of the antagonist in preparation of medicines for treating thrombotic diseases, wherein R is selected from C3-C8 cycloalkyl.
Owner:ZHEJIANG PHARMA COLLEGE
2-pyridyl trans-cyclohexane amides and uses
Owner:ZHEJIANG PHARMA COLLEGE
Compound containing nitrobenzene and diene adamantine structure and preparation method and application of compound
ActiveCN104447482AGood antithrombotic activityOrganic active ingredientsOrganic chemistryChemical compoundNitrobenzene
The invention relates to the field of medicine related to thrombotic diseases, in particular to a PAR-1 antagonist shown in the specification and containing a nitrobenzene and diene adamantine structure and a preparation method and application of the PAR-1 antagonist.
Owner:HONGGUAN BIO PHARMA CO LTD
Diene tetrazole aniline compound, its preparation method and use
The invention relates to the field of medicine related to thrombotic diseases, in particular to a PAR-1 antagonist containing a diene tetrazole aniline structure and a preparation method and usage of the PAR-1 antagonist. According to the structural formula of the PAR-1 antagonist, R1 is selected from H, C1-C5 alkyl bases and C3-C5 naphthenic bases.
Owner:肇庆市科至自动化设备有限公司
2-pyridyl trans-cyclohexane amide compound and application thereof
The invention relates to the field of thrombotic disease related medicines. Specifically, the invention relates to a formula (I) (shown in specifications) structured 2-pyridyl trans-cyclohexane amide structure-containing PAR-1 antagonist and application of the antagonist in preparation of medicines for treating thrombotic diseases.
Owner:ZHEJIANG PHARMA COLLEGE
Oxadiazole sulfoxide compound with alcoxyl substituted benzene and preparation method and application thereof
ActiveCN104529929AGood antithrombotic activityOrganic active ingredientsOrganic chemistryBenzeneDrugs preparations
The invention relates to the field of drugs relevant to thrombotic diseases, in particular to a PAR-1 antagonist of an oxadiazole sulfoxide structure with alkoxy p-substituted phenyl, a preparation method of the PAR-1 antagonist and the application of the PAR-1 antagonist of the oxadiazole sulfoxide structure with the alkoxy p-substituted phenyl in thrombotic disease treatment drug preparation. The structural general formula is specified in the specification, wherein R1 and R2 are defined in the specification.
Owner:珠海横琴长满欧国际贸易有限公司
Alkoxypyridyl-containing trans-cyclohexane amide compound and application thereof
InactiveCN104356058AGood antithrombotic activityOrganic chemistryBlood disorderPar 1 antagonistMedicinal chemistry
The invention relates to the field of thrombotic disease related medicines. Specifically, the invention relates to a trans-cyclohexane amide structured PAR-1 antagonist containing structures, such as alkoxy substituted pyridyl and the like, a preparation method of the antagonist and application of the antagonist in preparation of medicines for treating thrombotic diseases, wherein R is selected from C1-C3 alkyl and C3-C5 cycloalkyl.
Owner:ZHEJIANG PHARMA COLLEGE
A class of oxadiazole sulfoxide compounds containing cyanobenzene, its preparation method and use
ActiveCN104529930BGood antithrombotic activityOrganic active ingredientsOrganic chemistryBenzenePar 1 antagonist
The invention relates to the field of drugs associated with thrombotic diseases, in particular to a category of PAR-1 antagonists of an oxadiazole sulfoxide structure comprising nitrile substituted benzene, a preparation method of the PAR-1 antagonists, and application of drug combinations comprising the nitrile substituted benzene and the nitrile substituted benzene in preparation of the drugs for treating the thrombotic diseases. Please see the formula in the specification, wherein R is selected from -CN.
Owner:珠海横琴长满欧国际贸易有限公司
A kind of compound containing diene tetrazole structure, its preparation method and application
ActiveCN104496926BGood antithrombotic activityOrganic chemistryBlood disorderCombinatorial chemistryPar 1 antagonist
The invention relates to the field of pharmaceuticals for thrombotic diseases, in particular to a PAR-1 antagonist containing a diene tetrazolium and methoxyphenyl structure, a preparation method thereof and application thereof. According to the formula shown in the description, R1 is selected from H, alkyl of C1-C3 or cycloalkyl of C3-C5.
Owner:蚌埠市鼎荣科技信息咨询有限公司
Benzo diene tetrazole compound, preparation method and application of benzo diene tetrazole compound
InactiveCN104610184AGood antithrombotic activityOrganic chemistryBlood disorderTetrazolePar 1 antagonist
The invention relates to the field of drugs related to thrombotic diseases. Particularly, the invention relates to a PAR-1 antagonist with a benzo diene tetrazole structure as shown in the specification, a preparation method and an application of the PAR-1 antagonist. R1 is selected from alkyl of H and C1-C3, and a naphthenic base of C3-C5.
Owner:FOSHAN SAIWEISI MEDICINE SCI & TECH
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