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Iontophoretic drug delivery apparatus

a technology of ionophoretic and drug delivery, which is applied in the field of electrokinetic mass transfer of drugs, can solve the problems of inability to effectively use non-reusable applicators, localized burns, etc., and achieve the effects of improving the efficacy of topical agents, reducing the risk of harmful side effects, and low production cos

Inactive Publication Date: 2000-03-28
THE APS ORG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

It is an advantage of the present invention that the iontophoretic medicament applicator for large dermal areas improves the efficacy of topical agents and reduces the risk of harmful side effects that may occur with oral systemic treatment techniques.

Problems solved by technology

However, an effective nonreusable applicator heretofore has not been available.
However, such an applicator must employ an electrode that avoids current flowing along the path of least resistance into a lesion or skin rupture, resulting in a localized burn.

Method used

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Examples

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Embodiment Construction

FIG. 1 shows the control box for the iontophoretic drug delivery apparatus of the present invention. Control box, indicated generally by the numeral 10, is seen with a time adjustment dial to program the length of treatment, an alarm switch, a battery charge gauge for the rechargeable battery it contains, and a current check and adjustment control. The iontophoretic medicator has two electrode lead wires that lead from the positive electrode wire connection 11 and the negative wire electrode connection 12. These lead wires connect to two electrodes; one of which contains the ionic agent or medicament to be administered and the other which is the electric current distribution conductive member or grounding electrode.

Together these electrodes form a closed circuit through the patient's body when current is applied to promote the penetration or absorption of the ionic layer contained in the medicament of the working electrode. The polarity of the working electrode is selected based upo...

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Abstract

Improved apparatus for the iontophoretic transdermal delivery of medication across the membrane formed by the body's skin is provided so the medication can be absorbed by the adjacent tissues and blood vessels. The improved apparatus is not reuseable and can be adapted for large dermal area application or for smaller sized area application, based on the specific electrode employed.

Description

BACKGROUND OF THE INVENTIONThis invention relates generally to the electrokinetic mass transfer of medication transdermally and, more specifically, to improved apparatus for the iontophoretic delivery of medication across the membrane formed by the body's skin so the medication can be absorbed by the adjacent tissues and blood vessels.Iontophoresis has existed for several centuries as a means of applying medication locally through a patient's skin and for delivering medicaments to the eyes and ears. The application of an electric field to the skin was found to greatly enhance the skin's permeability to various ionic agents. The use of iontophoretic techniques has obviated the need for hypodermic injection of medication and medicaments, thereby eliminating the concomitant problems of trauma, pain and risk of infection to the patient.Iontophoresis involves the application of an electromotive force to drive or repel oppositely charged ions through the dermal layers into the area to be ...

Claims

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Application Information

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IPC IPC(8): A61N1/30
CPCA61N1/30
Inventor HENLEY, JULIAN L.
Owner THE APS ORG
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