Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Methods for the prevention and treatment of post-surgical complications

a post-surgical and complications technology, applied in the direction of biocide, heterocyclic compound active ingredients, drug compositions, etc., can solve the problems of affecting the healing effect of patients, so as to prevent or improve the formation of post-surgical complications.

Inactive Publication Date: 2002-08-13
ALCON INC
View PDF9 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some ocular surgeries. however, such as vitrectomy (posterior-segment surgery), cataract surgery or refractive surgery. may result in the development of post-surgical complications involving the formation of posterior subcapsular cataract ("PSC") and posterior capsule opacificatio
Due to the traumatic insult of such procedures, however. various inflammatory events or other tissue or cellular complications may arise.
In some cases following surgery, however, opacification of the posterior capsule forms, inhibiting clear vision and potentially necessitating further surgery.
Due to the severity of the surgical procedure, the posterior segment surgery process can cause tissue damage at both the acute and chronic phases of the recovery.
This is caused by breakdown of the blood aqueous and blood retinal barrier functions resulting in sustained vascular permeability and accumulation of plasma constituents in the ocular compartments following the surgical trauma.
Continued abnormal lens fiber cell growth leads to a progressive decay of lens optical properties due to localized suture defects in newly formed lens fiber layers.
However, these patents do not disclose specific methods of preventing surgery-induced formation of PCO or PSC, using systemic, topical or surgical irrigating solutions of the present invention.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Methods for the prevention and treatment of post-surgical complications
  • Methods for the prevention and treatment of post-surgical complications
  • Methods for the prevention and treatment of post-surgical complications

Examples

Experimental program
Comparison scheme
Effect test

example 1

The following example illustrates the reduction in frequency of post-vitrectomy cataract formation, employing a surgical irrigating solution containing a compound of formula (I).

Age-matched, Dutch Belted rabbits were used in this study. At 2.5 months of age, unilateral, partial vitrectomy (vitreous replaced by irrigating solution) was performed. Briefly, rabbits (1.5-2.0 kg) were prepared for surgery by subcutaneous administration of atropine to maintain heart rate and limit lung and oropharynx fluid accumulation. Animals were then anesthetized by intramuscular administration of ketamine (45 mg / kg) and xylazine (6 mg / kg). Anesthesia was maintained by re-administration of half-doses of anesthetic every 35-45 minutes as needed. For pupil dilatation, phenylephrine HCL and cyclopentolate HCL were administered topically to the surgical eye (OD). The nonsurgical eye (OS) received Duratears and was then taped shut to prevent loss of moisture. Immediately prior to surgery, proparacaine was ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
pressureaaaaaaaaaa
pressureaaaaaaaaaa
Opacitiesaaaaaaaaaa
Login to View More

Abstract

Methods for treating post-surgical formation of cataracts or posterior capsule opacification are disclosed. The methods utilize compositions containing certain compounds having an anti-inflammatory and anti-oxidant moiety covalently linked by and amide and ester bond.

Description

The present invention is directed to methods for the prevention, reduction or amelioration of surgery-induced formation of cataract or posterior capsular opacification.Various ocular surgeries are performed in an effort to improve vision. Some ocular surgeries. however, such as vitrectomy (posterior-segment surgery), cataract surgery or refractive surgery. may result in the development of post-surgical complications involving the formation of posterior subcapsular cataract ("PSC") and posterior capsule opacificationRefractive surgery typically involves the modification of the cornea in myopic patients to correct the focus of light on the retina. Examples of such surgeries include radial keratotomy (radial slices in the cornea), photorefractive keratotomy (laser ablation of the epitheilial and stromal layers of the cornea), LASIK (slicing a cornea flap and removing part of the stromal layer followed by the replacement of the flap), as well as procedures involving the insertion of cor...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(United States)
IPC IPC(8): A61K31/35A61K31/352A61K31/353A61K31/343
CPCA61K31/343A61K31/35A61K31/353A61K47/48061A61K47/4813Y10S514/912A61K47/545A61K47/555A61P27/00
Inventor GARNER, WILIAM H.GRAFF, GUSTAV
Owner ALCON INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com