Creatine, its derivatives, compositions and methods of use thereof
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example 1
Formulation Vehicles
[0104]As used in the present application, “WEP 442” represents water 40 parts, ethanol 40 parts and propylene glycol 20 parts by volume; “NEP 433” represents water 40 parts, ethanol 30 parts and propylene glycol 30 parts by volume; “WEP 244” represents water 20 parts, ethanol 40 parts and propylene glycol 40 parts by volume; “EP 55” represents an anhydrous composition with ethanol 50 parts and propylene glycol 50 parts by volume; and “WP 82” represents water 80 parts and propylene glycol 20 parts by volume.
example 2
Evaluation of Analgesic Effectiveness
[0105]Five scales were used to evaluate the efficacy of analgesic effect: 0 (zero) for no effect; 1+(25%), which represents partial relief of pain, itch, or eczema for less than 6 hours; 2+(50%), which represents substantial but incomplete relief of pain, itch, or eczema for less than 6 hours; 3+(75%), which represents complete relief of pain, itch, or eczema for less than 6 hours; and 4+(90-100%), which represents complete relief or eradication of pain, itch, or eczema for more than 6 hours
example 3
Preparation of Formulation of C12X4WEP442
[0106]HCl salt of ethyl creatinate 1 gram was dissolved in 24 ml of a solution prepared from water 40 parts, ethanol 40 parts and propylene glycol 20 parts by volume. L-arginine 0.15 gram was then added to the resulting solution raise the pH from 2.7 to 5.2. The formulation thus obtained contained 4% ethyl creatinate and was referred to as C12X4WEP442.
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