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Lycopene compositions and methods for protecting skin against ultraviolet radiation

Pending Publication Date: 2021-09-23
LYCORED
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a skincare composition that can be used to improve skin parameters in individuals. By using this composition, symptoms of skin issues can be reduced or eliminated.

Problems solved by technology

It is well established that prolonged exposure to sun has damaging effects on the skin.
Particularly, the ultraviolet (UV) radiation from the sun is known to cause erythema of the skin, sunburn and skin cancer.
However, the use of canthaxanthin is known to be limited due to adverse effects it may have on pigmentation.
The use of such a composition is limited by the negative effect pro-vitamin A carotenoids may have on the subject's health at certain dosage levels.
An excess of vitamin A, which is produced in the body from pro-vitamin A carotenoids, was found to have adverse effects on health.
However, Stahl has reported a problem in achieving desired carotenoid serum levels, suggesting poor bioavailability.

Method used

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  • Lycopene compositions and methods for protecting skin against ultraviolet radiation
  • Lycopene compositions and methods for protecting skin against ultraviolet radiation
  • Lycopene compositions and methods for protecting skin against ultraviolet radiation

Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of Lycopene Composition

[0114]The lycopene used throughout the Examples is natural Tomato lycopene by Lycored®.

[0115]Formulation 1: Each capsule (Lyc-044) contained:[0116]Lycopene 8.2 mg[0117]Vitamin E 2.9 mg[0118]Phytofluene and phytoene 3.00 mg[0119]Beta-carotene 0.46 mg[0120]Carnosic Acid 2 mg

[0121]In soft gel capsules which were prepared according to standard procedures known to the skilled artisan.

example 2

Effect of Lycopene Composition in Protection of Healthy Skin from UV-Induced Photo-Oxidative Damage

Methodology

[0122]A multicentre, double blind, placebo controlled parallel group clinical biostudy. After a 5-week run-in period, during which the intake of lycopene-rich foods and antioxidant supplements was restricted, subjects were randomized to receive formulation 1 soft gel capsules (Lyc-044) or identically appearing medium chain triglycerides soft gel capsules as placebo, twice daily for 12 weeks.

Number of Subjects (Planned and Analysed)

[0123]145 subjects completed the study and were analysed.

Diagnosis and Main Criteria for Inclusion

[0124]Healthy males and females, 20 to 55 years of age, with Fitzpatrick skin type I or II, BMI≤30 kg / m2 and healthy eating habits.

Test Product, Dose and Mode of Administration

[0125]Formulation 1 soft gel capsules administered orally twice daily.

Reference Therapy, Dose and Mode of Administration

[0126]Placebo administered orally twice daily.

Duration of ...

example 3

Lycopene, Phtyofluene and Phytoene Levels in the Serum of the Subjects

[0137]Methodology Compliance was measured by the increase in lycopene, phytofluene and phytoene levels during the study.

[0138]At the randomization visit (prior to receiving supplementation), mean lycopene, phytofluene and phytoene levels in the serum of the subjects of the Lyc-044 and placebo groups were similar. A statistically significant increase in mean lycopene, phytofluene and phytoene levels was observed after 4 weeks of treatment and at the end of the study in the Lyc-044 group compared to placebo (FIG. 3).

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Abstract

The invention is directed to compositions comprising lycopene and to methods of using the same, such as for improving one or more skin parameters, e.g., prevention or treatment of various skin-related conditions caused by ultraviolet radiation.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of priority of U.S. Provisional Patent Application No. 62 / 701,899 titled “LYCOPENE COMPOSITIONS AND METHODS FOR PROTECTING SKIN AGAINST ULTRAVIOLET RADIATION”, filed Jul. 23, 2019, the contents of which is incorporated herein by reference in its entirety.FIELD OF INVENTION[0002]This invention is directed to; inter alia, compositions comprising lycopene. More specifically, the present invention provides a composition comprising lycopene, which may be used, inter alia, in cosmetic compositions, ingestible skin care, treating skin-related conditions caused by ultraviolet radiation, or a combination thereof.BACKGROUND OF THE INVENTION[0003]It is well established that prolonged exposure to sun has damaging effects on the skin. Particularly, the ultraviolet (UV) radiation from the sun is known to cause erythema of the skin, sunburn and skin cancer. Protection of the skin from UV radiation can be achieved by p...

Claims

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Application Information

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IPC IPC(8): A61K8/31A61K31/015A61K31/191A61K31/355A61K9/00A61K8/365A61Q19/08A23L33/15
CPCA61K8/31A61K31/015A61K31/191A61K31/355A61K2800/92A61K8/365A61Q19/08A23L33/15A61K2800/522A61K9/0053A61P17/00A61K36/53A61K31/192A61K31/01A61K36/81A61Q17/04A61K2800/5922A61K2300/00A61Q19/00
Inventor KRUTMANN, JEANSHARONI, YOAVLEVY, JOSEPHLINNEWIEL HERMONI, KARIN
Owner LYCORED
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