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Prophylactic or therapeutic agent for autism spectrum disorder

a technology for autism spectrum disorder and therapy agent, applied in the field of medicine, can solve the problems of undetermined treatment method and a goal of permanent cure, and achieve the effect of prophylaxis or treatment of autism spectrum disorder

Inactive Publication Date: 2021-05-06
TAKEDA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a medication that contains a compound that can help prevent or treat autism spectrum disorder. This medication is designed to have an affinity for melatonin receptors, which are believed to be involved in the development of autism. The technical effect of this patent is to offer a potential treatment for autism spectrum disorder using a compound with melatonin receptor affinity.

Problems solved by technology

At present, a treatment method has not been established yet, and improvement of life has been attempted by prescribing drugs.
However, it is a symptomatic treatment and does not aim at permanent cure.

Method used

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  • Prophylactic or therapeutic agent for autism spectrum disorder
  • Prophylactic or therapeutic agent for autism spectrum disorder
  • Prophylactic or therapeutic agent for autism spectrum disorder

Examples

Experimental program
Comparison scheme
Effect test

production example 1

N-[2-(6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-ylidene)ethyl]acetamide

[0189]

production example 2

N-[2-(6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-ylidene)ethyl]propionamide

[0190]

production example 3

N-[2-(2-methyl-6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-ylidene)ethyl]acetamide

[0191]

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PUM

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Abstract

The present invention provides a prophylactic or therapeutic agent for an autism spectrum disorder containing compound (I) having melatonin receptor affinity. A compound represented by the formula:wherein each symbol is as described in the specification, or a salt thereof.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a divisional of U.S. patent application Ser. No. 16 / 068,553, filed on Jul. 6, 2018, which is a U.S. National Phase of International Patent Application No. PCT / JP2017 / 000166, filed on Jan. 5, 2017, which claims priority to U.S. Provisional Patent Application No. 62 / 276,354, filed on Jan. 8, 2016, the contents of each of which is incorporated by reference herein in its entirety.TECHNICAL FIELD[0002]The present invention relates to a medicament containing a compound possibly having melatonin receptor affinity and expected to be effective for the prophylaxis or treatment of an autism spectrum disorder.BACKGROUND OF THE INVENTION[0003]Autistic spectrum disorder is said to be one of neurodevelopmental disorders characterized by the symptoms of social disorder (e.g., social communication disturbance, interpersonal mutual reaction disorder and the like), restricted repetitive modalities (e.g., behavior, interests, activities a...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07D263/52A61K31/428A61K31/423A61P25/00C07D277/60C07D413/06
CPCC07D263/52A61K31/428C07D413/06A61P25/00C07D277/60A61K31/423A61P25/18
Inventor HIRAI, KEISUKEISHIKAWA, TAKASHI
Owner TAKEDA PHARMA CO LTD
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