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Methods and devices for treating a retinal detachment

a retinal tear and retinal pigment technology, applied in the field of retinal tear treatment, can solve the problems that the capacity of the retinal pigment epithelium to remove subretinal fluid exceeds the flow through the tear in the retina and into the subretinal space, so as to reduce the rate of subretinal fluid accumulation, and slow the diffusion of water

Inactive Publication Date: 2021-03-04
VITREAN INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0007]One aspect of the present invention relates to a non-intuitive, unexpected and unique approach to treating a retinal detachment by using a substance that when inserted into the vitreous cavity of an eye with a retinal detachment slows the diffusion of water and / or solutes through the vitreous cavity, and secondarily through the retina break, thereby reducing the rate of subretinal fluid accumulation. By sufficiently reducing the rate of subretinal fluid accumulation, fluid removal by the retinal pigment epithelium can outpace accumulation through the retinal tear. The result is reattachment of the retina without the need for a tamponade agent.
[0009]One aspect of the invention provides a method of treating a detachment of a retina of an eye. In some embodiments the method includes the steps of injecting a substance into a vitreous cavity of the eye, the substance slowing flow of fluid through the vitreous cavity into a subretinal space to reduce a rate of accumulation of a subretinal fluid in the subretinal space to below a rate of removal of the subretinal fluid from the subretinal space by retinal pigment epithelium; and permitting the retinal pigment epithelium to reattach the retina. In some embodiments, the substance also slows flow of the fluid through a tear in the retina into the subretinal space.
[0010]Some embodiments of the method include the step of increasing a viscosity of the fluid in the vitreous cavity. The fluid may be, e.g., vitreous fluid or a fluid that has replaced natural vitreous fluid.

Problems solved by technology

However, in some instances, flow through the tear in the retina and into the subretinal space exceeds the capacity of the retinal pigment epithelium to remove subretinal fluid.
Unrepaired, these types of retinal detachments uniformly lead to blindness.
Unfortunately, only certain types of retinal tears are candidates for this non-surgical procedure, which requires strict patient positioning and altitude restrictions, and is successful only 50% of the time.

Method used

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  • Methods and devices for treating a retinal detachment
  • Methods and devices for treating a retinal detachment
  • Methods and devices for treating a retinal detachment

Examples

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Creation of 20% Hyaluronic Acid Solution

[0070]The plunger from a 10 mL luer lock syringe was removed and the syringe capped. The barrel of the syringe was filled with 1.0 gram of pharmaceutical grade hyaluronic acid 700 kDa, bioburden <10 cfu / g, endotoxin <0.01 EU / mg (Lifecore Biomedical LLC, Chaska, Minn.). The barrel of the syringe was then slowly filled with 4.5 mL phosphate buffered saline, pH 7.4 (Thermo Fisher Scientific, Waltham, Mass.) and 500 μL of 100× combination streptomycin, penicillin, amphotericin B (Thermo Fisher Scientific, Waltham, Mass.). The plunger was then reinserted into the barrel of the syringe. The syringe plunger was depressed to approximately halfway down the syringe barrel, pushing the phosphate buffered saline through the hyaluronic acid powder to the capped end of the syringe. Initially the solution was heterogenous and lacked transparency. The syringe was placed at 4° C. overnight. After 24 hours, the solution contained many small fixed bubbles, but t...

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Abstract

A method of treating a detachment of a retina of an eye, the method including the steps of injecting a substance into a vitreous cavity of the eye, the substance slowing flow of fluid through the vitreous cavity into a subretinal space to reduce a rate of accumulation of a subretinal fluid in the subretinal space to below a rate of removal of the subretinal fluid from the subretinal space by retinal pigment epithelium; and permitting the retinal pigment epithelium to reattach the retina. The invention also includes devices for practicing the method.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. application Ser. No. 15 / 854,486, filed Dec. 26, 2017; which application claims the benefit of U.S. Application No. 62 / 441,817, filed Jan. 3, 2017, and U.S. Application No. 62 / 470,324, filed Mar. 12, 2017, each of which is herein incorporated by reference in its entirety.INCORPORATION BY REFERENCE[0002]All publications and patent applications mentioned in this specification are incorporated herein by reference in their entirety to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference.BACKGROUND[0003]Retinal detachment is a vision threatening disease affecting approximately 1 in 10,000 people worldwide. While there are different causes of a retinal detachment, by far the most common type is due to a tear in the retina. This break in the integrity of the retina allows fluid from the anterior chamber to flow...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/14A61K9/00A61K9/08A61F9/007A61K31/43A61K31/7048A61F9/00A61K31/7036A61K47/38
CPCA61K9/146A61K9/0048A61K9/14A61K9/08A61F9/00727A61K47/38A61K31/7048A61F9/0017A61K31/7036A61F9/0008A61K31/43A61P27/02
Inventor SCHACHAR, IRA HYMANSCHACHAR, RONALD A.
Owner VITREAN INC
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