Methods and formulations promoting tissue/organ regeneration, longevity and healthspan

Abstract

A method includes a step of identifying a subject in need of diet modification; and administering a first diet to the subject for a first time period. The first diet provides 4.5 to 7 kilocalories per pound of subject for a first day and 3 to 5 kilocalories per pound of subject per day for a second to fifth day of the first diet. The first diet includes less than 30 g of sugar on the first day; less than 20 g of sugar on the second to fifth days; less than 28 g of proteins on the first day; less than 18 g of proteins on days the second to fifth days; 20 to 30 grams of monounsaturated fats on the first day; 10 to 15 grams of monounsaturated fats on the second to fifth days; and between 6 and 10 grams of polyunsaturated fats on the first day.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of U.S. provisional application Ser. No. 61 / 716,676 filed Oct. 22, 2012, Ser. No. 61 / 736,308 filed Dec. 12, 2012, and Ser. No. 61 / 746,787 filed Dec. 28, 2012, the disclosures of which are incorporated in their entirety by reference herein.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT[0002]The invention was made with Government support under Contract Nos. PO1AG034906, P01 AG 034906-01, and PO1AG020642. The Government has certain rights to the invention.TECHNICAL FIELD[0003]The present invention relates to a method of promoting tissue and / or organ regeneration.BACKGROUND[0004]Regenerative therapies may be used in the replenishment of damaged tissues / organs caused by chemotherapy or radiotherapy, associated with degenerative diseases or aging.[0005]Conventional regenerative therapies commonly rely on the introduction of donor-derived regenerative cells and / or the administration of biologi...

AI Technical Summary

Benefits of technology

[0013]In another embodiment, a method of increasing the number of stem cells and / or progenitor cells in a subject is provided. In accordance with the method, a subject requiring increased numbers of stem cells and / or progenitor cells is identified and a reduction in protein kinase A (PKA) activity is induced.

[0017]In still another embodiment, a method of alleviating a symptom of Alzheimer's Disease is provided. The method includes a step of administering an amino acid specific diet having certain amino acids. In this embodiment, a long-term alternation of cycles of a normal and a protein restricted diet (protein restriction cycles, PRC) is found to reduce GHR / IGF-1 levels / signaling and ameliorate the AD-like symptoms in a 3×Tg-AD mouse that accumulates both Aβ and tau pathologies.

Problems solved by technology

Besides ethical issues, technical and safety challenges in stem cell isolation, maintenance, expansion, donor-recipient matching and transplantation persist and limit the usefulness and practicability of existing conventional regenerative therapies.

Conventional therapies typically have not utilized dietary protocol has effective treatments for patients in need of tissue regeneration.

The major limitation of conventional therapies is the lack of a coordinated regenerative process that is reminiscent of the developmental process leading to tissue generation in the embryo.

Because CR is very difficult to maintain, and is unavoidably associated with weight loss, loss of sex drive, hunger, feeling cold at normal room temperature and possible immune system side effects.

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