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Regulation of Brain Biogenic Amines Associated with Depression by a Formulation from Botanical Source

a technology of biogenic amines and botanical sources, applied in the field of plant based formulations, can solve problems such as the burden of disease for women, and achieve the effects of improving emotional, cognitive and social impairment, reducing the burden of disease, and improving sleep

Inactive Publication Date: 2016-06-09
SHAH B ARVIND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent proposes a plant-based formulation that may help improve sleep and mood in people with depression by increasing melatonin levels and improving circadian rhythms. The formulation is safe and effective, and can be used as a treatment for depression, which is a common and debilitating condition. The study also highlights the need for affordable and cost-effective treatments for depression.

Problems solved by technology

In fact depression is the leading cause of disease burden for women in both low as well as high income countries.

Method used

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  • Regulation of Brain Biogenic Amines Associated with Depression by a Formulation from Botanical Source
  • Regulation of Brain Biogenic Amines Associated with Depression by a Formulation from Botanical Source

Examples

Experimental program
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example

Example-1

[0044]When the aqueous extract of Nyctanthes arbortristis (75 mg / kg), Ocimum tenuiflorum (75 mg / kg) and Hippophae salcifolia (50 mg / kg) was administered orally to animals of sleep deprivation stress model exhibited its activity as 5-HT antagonist as well as melatonin agonist effects suggesting improved sleep pattern as well as its anti-depressant potentials. The drug is having 5-HT2c receptor antagonist activity as it inhibits serotonin re-uptake by acting on several neuroplasticity associated molecules in the associated brain region. 5-HT antagonism will predominate on melatonergic action.

example-2

[0045]The aqueous extract of Ocimum tenuiflorum in the dose of 125 mg / kg and Hippophae salcifolia in the dose of 125 mg / kg mixed and given to experimentally designed sleep deprived rats a significant reduction in glutamate content was noticed along with increase in GABA synthesis, suggesting the improved brain fimction impairment in terms of anti-depressant activity of test drug. Overall the neuronal plasticity was enhanced. The test formulation acted as MT1 and MT2 agonist and maintained the hippocampal volume,

example-3

[0046]After determination of safety and efficacy of test formulation in pre-clinical studies the test formulation was utilized for human consumption. When the aqueous extract of Nyctanthes arbortristis in the dose of 425 mg / day and Ocimum tenuiflorum in the dose of 450 mg / day was mixed and given to selected cases of mild to moderate depression, improvement in loss of interest in various activities, loss of self esteem, loss

of energy and depressed mood was noticed through its activity on neurotransmitter biochemistry.

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Abstract

Provided herein are anti depressant and anxiolytic herbal formulations including: 225-450 mg of Nyctanthes arbortristis, 250-550 mg Ocimum tenuiflorum, 200-450 mg Hippophae salcifolia, and optionally additives selected from minerals, vitamins, salt, filler and binder. Also provided are methods of making such formulations and methods of using such formulations for treating or improving brain function.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to Indian Patent Application No. 6161 / CHE / 2014, filed on Dec. 6, 2014.FIELD OF INVENTION[0002]Present invention relates to the development of a plant based formulation beneficial in the management of mild to moderate depression. This preparation may be further advantageous if used for the management of sleep disorders, behavioral abnormalities like psychotic and neurotic behavior, cognitive dysfunction, etc. The pharmacological activity of test formulation can be evaluated on neurotransmitter biochemistry including biogenic amine like dopamine, GABA, glutamate, 5-HT serotonin and also anxiety and depression scores as these bio-markers are significantly involved with depressive behavior. Melatonin is one of the most important targeted markers involved with depression and having a role in regulation of sleep. The activity of test formulation can be assessed on melatonin receptors distributed in different par...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K36/63A61K36/185A61K45/06A61K36/53
CPCA61K36/63A61K45/06A61K36/185A61K36/53A61K2300/00
Inventor DUBEY, RAJESHDUBEY, SHIPRADUBEY, GOVIND PRASADAGRAWAL, ARUNASHAH, B. ARVINDSHAH, ANAND
Owner SHAH B ARVIND
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