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Bioprosthetic heart valves having adaptive seals to minimize paravalvular leakage

a bioprosthetic heart valve and adaptive seal technology, applied in the field of heart valve prosthesis, can solve the problems of expanding and rendering the heart valve unusabl

Inactive Publication Date: 2015-05-07
EDWARDS LIFESCIENCES CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent is about a new heart valve design that doesn't require selective encapsulation in a liquid storage solution. This means that the valve can be in contact with the liquid while keeping its adaptive seal separate from it. This is important because if the adaptive seal is not encapsulated, it can expand and make the heart valve unusable. The design also allows for a simpler and more efficient manufacturing process.

Problems solved by technology

Storage in liquid preservative solutions introduces a host of challenges for valves which include adaptive seals, particularly for those which are activated to expand upon exposure to liquid.
If the adaptive seal is not selectively encapsulated from the liquid storage solution, it will expand and render the heart valve unusable.

Method used

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  • Bioprosthetic heart valves having adaptive seals to minimize paravalvular leakage
  • Bioprosthetic heart valves having adaptive seals to minimize paravalvular leakage
  • Bioprosthetic heart valves having adaptive seals to minimize paravalvular leakage

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Embodiment Construction

[0048]Specific, non-limiting embodiments of the present invention will now be described with reference to the drawings. It should be understood that such embodiments are by way of example only and merely illustrative of but a small number of embodiments within the scope of the present invention. Various changes and modifications obvious to one skilled in the art to which the present invention pertains are deemed to be within the spirit, scope and contemplation of the present invention as further defined in the appended claims.

[0049]FIGS. 1A and 1B depict a transcatheter heart valve 100 that has been expanded and implanted within an arterial wall 1. The transcatheter heart valve 100 generally comprises a biological tissue leaflet structure 110 that is coupled to an expandable frame or stent 120. It is understood that the stent 120 can either be self-expanding or balloon-expandable. The heart valve 100 further comprises an inflow portion 102, an outflow portion 104 and a skirt 125 tha...

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Abstract

A packaged bioprosthetic heart valve comprising a bioprosthetic heart valve, an adaptive seal and a package. The bioprosthetic heart valve comprises an at least partially dehydrated biological tissue leaflet structure coupled to a supporting frame. The bioprosthetic heart valve has a periphery, an inflow portion, and an outflow portion. The adaptive seal is coupled to the bioprosthetic heart valve around at least a portion of the periphery. The adaptive seal comprises an expandable material that expands after exposure to an initiating condition. The bioprosthetic heart valve and the adaptive seal is stored and contained within the package, which does not contain a liquid storage solution in contact with the bioprosthetic heart valve and the adaptive seal.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims the benefit of U.S. Patent Application No. 61 / 900,827, filed Nov. 6, 2013, the entire disclosure of which is incorporated by reference.FIELD OF THE INVENTION[0002]The invention relates to a heart valve prosthesis and, more particularly, to a heart valve prosthesis having an adaptive seal that minimizes perivalvular leakage following implantation.BACKGROUND[0003]Perivalvular leakage (PVL) is a complication that is related to the replacement of heart valves. It occurs when blood flows through a channel or gap between the structure of an implanted valve and the cardiac or arterial tissue due to a lack of appropriate sealing.[0004]Intimate apposition of replacement heart valves and the surrounding cardiac or arterial walls seals the valve and minimizes PVL. In certain cases, however, a seal cannot be achieved, leaving irregular gaps of different sizes and shapes between the valve and the cardiac or arterial walls. This ...

Claims

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Application Information

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IPC IPC(8): A61B19/02A61F2/24
CPCA61B19/026A61B2019/0201A61F2/2412A61F2/2415A61B50/30A61B50/33A61B2050/002A61F2/0095A61F2/2418A61F2250/0069
Inventor ZENG, QINGGANGLIMSAKOUNE, CHACPHETKO, DIANA E.AGUILA, CHRISTINA M.
Owner EDWARDS LIFESCIENCES CORP
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