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Glomerulonephritis biomarkers

a glomerulonephritis and biomarker technology, applied in the field of glomerulonephritis biomarkers, can solve the problems of increased risk of gn, blood and protein loss in urine, and difficulty in determining gn,

Inactive Publication Date: 2014-08-07
MESO SCALE TECH LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a method for evaluating the effectiveness of a treatment regimen for glomerulonephritis (GN) by measuring the levels of biomarkers in a patient's sample. The biomarkers include Clusterin, KIM-1, aGST, IL-6, CHGA, E-Cadherin, Timp-1, TNF-RI, TNF-RII, UMOD, OPGN, Calbindin, Osteoactin, Albumin, B2M, Cystatin C, NGAL, MCP-1, IL-15, ICAM-1, KDR, LBP, PRDX4, Prolactin, PSAT1, S100A4, TIMP-1, VCAM-1, EGF, and others. The levels of these biomarkers are compared to a normal control level and the patient's response to the treatment regimen is evaluated. This method can help to personalize treatment for GN and improve patient outcomes.

Problems solved by technology

Damage to the glomeruli causes blood and protein to be lost in the urine.
While the exact cause of GN can be difficult to determine, it can be caused by immunological problems.
A quarter of people with chronic GN have no history of kidney disease, but certain conditions can increase an individual's risk of developing GN, including but not limited to, blood or lymphatic system disorders, exposure to hydrocarbon solvents, and a history of cancer, infections such as strep infections, viruses, heart infections, or abscesses.

Method used

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Measurement of biomarkers indicative of Glomerulonephritis

[0091]Urine and serum samples were collected from 23 patients previously diagnosed with GN and 6 normal control subjects (patients having normal kidney function). Samples were analyzed in an immunoassay format and the samples were screened for the presence / absence of the following set of biomarkers: AKR1B1, AKR1C2, Albumin, ALP, ANXA1, B2M, BCL2L2, Calbindin, CHGA, Clusterin, CRYAB, Cystatin C, E-Cadherin, EGF, EOTAXIN, EOTAXIN-3, FABP5, GCLM, GLO1, GM-CSF, GPI, GSTM1, GSTM2, ICAM-1, IFN-gamma, IFN-gamma, IL-10, IL-12P70, IL-13, IL-15, IL-16, IL18, IL-1 alpha, IL-1 beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IP-10, KDR, KIM-1, LBP, MAGEA4, MAPK14, MBD1, MCP-1, MCP-4, MDC, MIP-1B, NGAL, NME2, OCL, ODC1, ONN, OPGN, OPN, osteoactivin, Osteopontin, P-Cadherin, PPP2R4, PRDX4, Prolactin, PSAT1, RAC1, RANTES, S100A4, S100A6, SAT1, SERPINB3, SFN, SOST, TARC, TFF3, TIMP-1, TNF RI, TNF RII, TNF-alpha, UMOD, VCAM-1, VEGF and aGST.

[0092]In...

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Abstract

The present invention relates to methods of diagnosing glomerulonephritis (GN) in a patient, as well as methods of monitoring the progression of GN and / or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]The present application claims benefit of U.S. Provisional Application No. 61 / 759,434 filed on Feb. 1, 2013, the entire contents of which are incorporated herein by reference.FIELD OF THE INVENTION[0002]This application relates to assay methods useful in the detection and treatment of glomerulonephritis.BACKGROUND OF THE INVENTION[0003]Glomerulonephritis, also known as glomerular nephritis, abbreviated GN, is a renal disease (usually of both kidneys) characterized by inflammation of the glomeruli, or small blood vessels in the kidneys. GN is a type of renal disease in which the part of the kidneys that filter waste and fluids from the blood is damaged. Damage to the glomeruli causes blood and protein to be lost in the urine. While the exact cause of GN can be difficult to determine, it can be caused by immunological problems. GN can develop quickly, and kidney function can be lost within weeks or months (called rapidly progressive GN). A ...

Claims

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Application Information

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IPC IPC(8): G01N33/68A61M1/36A61M1/16A61M1/34
CPCG01N33/6893A61M1/1603A61M1/3624A61M1/3496A61M1/1676G01N2800/347G01N2800/52
Inventor GLEZER, ELI N.KENTEN, JOHNNIKOLENKO, GALINA
Owner MESO SCALE TECH LLC
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