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Methods, Systems and Devices for Treatment of Cerebrospinal Venous Insufficiency and Multiple Sclerosis

a cerebrospinal vein and multiple sclerosis technology, applied in the field of biology and medicine, can solve the problems of ms being difficult to diagnose in its early stages, neuroaxonal apoptosis and degeneration, and unable to cure ms, so as to improve the and improve the effect of flow through the stenotic body lumen

Inactive Publication Date: 2013-08-15
EXPLORAMED DEV LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides endovascular devices that can be implanted in a stenotic region of a body lumen and modified after initial implantation to optimize their efficacy and minimize untoward effects. These devices can be self-expandable or pressure-expandable, and can be used to improve flow through a stenotic body lumen by delivering energy to cause shrinkage, contraction, or other movement of tissue or obstructive matter in the lumen. The invention also includes methods for improving flow through a stenotic body lumen by delivering material or implanting magnets to enlarge the stenotic region or shield it from compression or contraction. The invention also provides methods for preventing or deterring movement or migration of the endovascular device after implantation.

Problems solved by technology

Multiple sclerosis (MS) causes demyelination and scarring of the axons, which in turn results in impaired conduction of action potentials, neuroaxonal apoptosis and degeneration.
MS is difficult to diagnose in its early stages.
There is no known cure for MS and the specific pathophysiology by which MS progresses is not fully understood.
MS is not considered a hereditary disease but certain genetic variations are associated with increased risk of developing MS.
The patient's immune system can then activate those T lymphocytes, causing autoimmune damage to the neural cells.
However, this initial study, the devices and techniques employed were generally designed for treatment of other types of obstructions in other lumens of the body and, thus, are less than optimal for use in this application.
Also, other investigators have failed to confirm any increased incidence of CCVI in MS patients.
One recent publication has reported that the re-stenosis rate following angioplasty without stenting was unacceptably high (approximately 50% for internal jugular vein occlusions) and that such re-stenosis was often accompanied by worsening neurological symptoms.
Generally, use of these stents is less than optimal because a number of adverse complications can occur.
None of the existing methods, devices or systems are believed to be optimal for treating all cases of chronic cerebrospinal venous insufficiency in MS patients.
There is an absence in the market of dedicated devices of the proper size, length and functional characteristics for treating CCVI.
Using existing stents at the level of the internal jugular vein and / or azygous vein creates risk of displacement, migration along the vein, stenosis, thrombosis, thromboembolism, migration thru and / or perforation of the venous wall and pulmonary migration, thus affecting venous outflow.

Method used

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  • Methods, Systems and Devices for Treatment of Cerebrospinal Venous Insufficiency and Multiple Sclerosis
  • Methods, Systems and Devices for Treatment of Cerebrospinal Venous Insufficiency and Multiple Sclerosis
  • Methods, Systems and Devices for Treatment of Cerebrospinal Venous Insufficiency and Multiple Sclerosis

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Embodiment Construction

[0104]The following detailed description and the accompanying drawings to which it refers are intended to describe some, but not necessarily all, examples or embodiments of the invention. The described embodiments are to be considered in all respects only as illustrative and not restrictive. The contents of this detailed description and the accompanying drawings do not limit the scope of the invention in any way.

[0105]FIG. 1A is a schematic diagram of the major veins of the human brain with the names of specific veins labeled thereon. FIG. 1B is a schematic diagram showing major veins of the neck and upper thorax through which venous blood drains from the veins of the brain. Reference letters are used to indicate specific veins, as follows:

LabelVesselSVCSuperior Vena CavaRIRight InominateLILeft InominateRSRight SubclavianLSLeft SubclavianRIJRight Internal JugularLIKLeft Internal JugularREJRight External JugularLEJLeft External JugularITVInferior Thyroid VeinsMTVMiddle Thyroid VeinsS...

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Abstract

Methods and devices for relieving stenoses in, or otherwise improving blood flow through, body lumens. Although applicable in a variety of different body lumens, the methods and devices of this invention are specifically useable for relieving stenoses in, or otherwise improving blood flow through, veins which drain blood from the brain for treatment of multiple sclerosis or other neurodegenerative disorders that are caused, triggered or exacerbated by venous occlusion or venous insufficiency.

Description

RELATED APPLICATION[0001]This application claims priority to U.S. Provisional Patent Application Ser. No. 61 / 303,274 filed Feb. 10, 2010, the entire disclosure of which is expressly incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention relates generally to biology and medicine and more particularly to methods, systems and devices for treating venous obstruction or venous insufficiency and for treatment of neurological or other disorders, such as multiple sclerosis (MS), which may be associated with venous obstruction or insufficiency.BACKGROUND OF THE INVENTION[0003]Pursuant to 37 CFR 1.71(e), this patent document contains material which is subject to copyright protection. The copyright owner has no objection to facsimile reproduction of the complete patent document or the patent disclosure, as it appears in the Patent and Trademark Office patent file or records, but otherwise reserves all copyright rights whatsoever.[0004]Nerve cells of the central nerv...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61F2/06A61F2/82A61F2/89A61F2/915
CPCA61F2/885A61F2/89A61F2/915A61F2230/0054A61F2/06A61F2220/0008A61F2220/0016A61F2002/825
Inventor MAKOWER, JOSHUABRIGHT, II, EARL A.BENDER, THEODORE M.CANTANESE, III, JOSEPHCHANG, JOHN Y.KING, THOMASSLONE, CLINTONLAMSON, THEODORE C.IMRAAN, AZIZ
Owner EXPLORAMED DEV LLC
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