Dispersible phospholipid stabilized microparticles
a technology of phospholipid stabilized microparticles and microparticles, which is applied in the direction of microcapsules, drug compositions, immunological disorders, etc., can solve the problems of irreversible lattices, and achieve the effect of improving the dispersibility of micronized particles
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[0028]The present invention of a rapidly dispersing, solid medicament is illustrated by way of the examples cited in Table 1. Compositions noted in this table are expressed on % weight basis of the dried product. It is understood that the bulking agent may be added to the suspension prior to the homogenization step or prior to the drying step.
TABLE 1Composition (% w / w) and Attributes of Solid Dosage Form ExamplesAttributesFormu-Particle ParticlelationAdditional SurfactantsDisinte-SizeSizeNum-PhospholipidsMyrjPVPTweenActive IngredientBulking Agentgrationpre-Lyopost-LyoberE80P100H5217NaDeox80CyAITRFENTYPEQtyTYPEQtyTime (sec)(micron)(micron)1——————33——LAC67——510.613.32——————62.5——PVP1737.5——510.217.43——4.6—1.1—23——MAN5.5LAC46 600.6648.9423.1———————76.9————>2 min.0.9185.505—5.6———5.6——27.8MAN61.0——100.976.7369.1———————33.3SUC45.5SOR15.150.970.98711.1——————27.8—TRE33.3LAC27.851.151.15815.4——————38.4—TRE46.2——51.151.129—8.44.2—1.0—21.1——MAN23.2LAC42.1150.921.3310—11.96.017.91.5—29.9——MAN...
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