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Methods of Treating Epiphora

a technology of epiphora and epiphora gel, which is applied in the direction of biocide, plant/algae/fungi/lichens, biocide compositions, etc., can solve the problems of insufficient or misdirected drainage of naturally produced tears, impaired tear clearance, and “back up

Inactive Publication Date: 2011-04-28
FRIEDLAENDER MITCHELL H +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These causes are usually associated with inadequate, or misdirected, drainage of naturally-produced tears.
If there is blockage, or a narrowing, of the tear drainage system, clearance of tears can be impaired, and the tears can “back up,” accumulate in the eyes, or run down the face.
In some instances, epiphora is due to excessive production of tears.
Excessive tearing can also be caused by irritation of the eye from debris on the eyelids, or from misdirected eye lashes.

Method used

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  • Methods of Treating Epiphora
  • Methods of Treating Epiphora

Examples

Experimental program
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Effect test

example 1

[0078]The gel matrix of the present invention was produced by mixing the ingredients of Table 1.

TABLE 1Ingredient% w / wCamphor4.8Eucalyptus Oil1.2Menthol2.6Polyethylene Glycol 335030Polyethylene Glycol 30061.4

[0079]The polyethylene glycol (PEG) components were mixed, melted and heated to give a homogeneous vehicle. The active ingredients (camphor, eucalyptus oil, and menthol) were then added and mixed into the homogeneous vehicle until dissolved. The solution was cooled to room temperature while mixing to maintain homogeneity.

example 2

[0080]The composition of Example 1 was administered just inside the external nares of 15 subjects who had bothersome tearing in one or both eyes. The composition was administered one time / day for 14 days. After 14 days, six of the subjects had complete, or near complete, elimination of epiphora, three had some improvement, and six had no improvement. There were no adverse events.

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Abstract

The present invention is related to a method for treating epiphora, the method comprising administering to a nasal area of a subject in need thereof a composition comprising camphor, eucalyptus oil, and menthol, wherein the composition is substantially free of lipids other than the eucalyptus oil.

Description

[0001]This application claims the benefit of the filing date of U.S. Appl. No. 60 / 856,007, filed Nov. 2, 2006, the entirety of which is fully incorporated by reference herein.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention is related to methods of treating epiphora, the methods comprising administering to a nasal area or ocular area of a subject in need thereof a composition comprising camphor, eucalyptus oil, and menthol, wherein the composition is substantially free of lipids other than the eucalyptus oil.[0004]2. Background Art[0005]Tears are continuously produced by the lacrimal and accessory lacrimal glands, and bathe the eye with a complex fluid consisting of aqueous, mucinous, and oily components. Tears drain through the lacrimal puncta, small openings at the inner edge of the upper and lower eyelids, through canals (the canaliculi), into the nasolacrimal duct, and finally into the nose. Excessive tearing, or watering of the eyes, is know...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K36/61A61P27/00
CPCA61K36/53A61K36/00A61P27/00A61P27/02
Inventor FRIEDLAENDER, MITCHELL H.TAKRURI, HARUN
Owner FRIEDLAENDER MITCHELL H
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