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Combination of HMG-COA Reductase Inhibitors with Phosphodiesterase 4 Inhibitors for the Treatment of Inflammatory Pulmonary Disease

a technology of phosphodiesterase 4 and reductase inhibitor, which is applied in the direction of cardiovascular disorders, drug compositions, peptide/protein ingredients, etc., can solve the problems of single mediator or cell type targeting that has not led to satisfactory results, and the success rate of instances limited

Inactive Publication Date: 2010-03-18
TAKEDA GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0107]Conclusion: The combination of sub-effective doses of the PDE4 inhibitor COMPOUND A and the HMG-CoA reductase inhibitor ATORVASTATIN hemi-calcium sesqui-hydrate unexpectedly showed a potent (synergistic) and effective inhibition of inflammatory processes.

Problems solved by technology

Therefore, in medical practice for the treatment of e.g. asthma and COPD the targeting of a single mediator or cell type has not lead to satisfactory results.
For both asthma and COPD at present combination therapies are used but in many instances with limited success especially in COPD.

Method used

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  • Combination of HMG-COA Reductase Inhibitors with Phosphodiesterase 4 Inhibitors for the Treatment of Inflammatory Pulmonary Disease
  • Combination of HMG-COA Reductase Inhibitors with Phosphodiesterase 4 Inhibitors for the Treatment of Inflammatory Pulmonary Disease
  • Combination of HMG-COA Reductase Inhibitors with Phosphodiesterase 4 Inhibitors for the Treatment of Inflammatory Pulmonary Disease

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Embodiment Construction

[0009]It has now been found that the combined use of a PDE4 inhibitor and a HMG-CoA reductase inhibitor potentiates the anti-inflammatory effect of either component alone.

[0010]Therefore, according to a first aspect of the present invention there is provided a pharmaceutical composition comprising a pharmaceutical formulation including an amount of a PDE4 inhibitor or a pharmaceutically acceptable salt thereof, an amount of a HMG-CoA reductase inhibitor or a pharmaceutically acceptable salt thereof, wherein the first amount and the second amount together comprise an effective amount for the preventive or curative treatment of an inflammatory pulmonary disease, and at least one pharmaceutically acceptable auxiliary.

[0011]The above-mentioned pharmaceutical composition provides for the administration of a PDE4 inhibitor or a pharmaceutically acceptable salt thereof with a HMG-CoA reductase inhibitor or a pharmaceutically acceptable salt thereof and is thus presented as a single formula...

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Abstract

The invention relates to the combined use of a PDE4 inhibitor with a HMG-CoA reductase inhibitor for the preventive and curative treatment of an inflammatory pulmonary disease.

Description

TECHNICAL FIELD[0001]The present invention relates to the combination of certain known therapeutic compounds for therapeutic purposes. The substances used in the combinations according to the invention are known active agents from the phosphodiesterase 4 (PDE4) inhibitor class and active agents from the HMG-CoA-reductase inhibitor class.BACKGROUND ART[0002]Statins are widely used as cholesterol lowering therapeutic agents. They reduce cholesterol levels through competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the key enzyme that regulates cholesterol synthesis. The cholesterol-lowering effect of statins is also due to an increase in the uptake of cholesterol by cells as a result of intracellular cholesterol depletion and enhanced expression of low-density lipoprotein (LDL) receptors.[0003]However, statins exhibit properties that are beyond their lipid-lowering effects. These non-lipid-lowering properties involve the inhibition of the isoprenoid pa...

Claims

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Application Information

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IPC IPC(8): A61K31/502A61K31/437A61K31/4439A61K31/44A61K31/40A61K31/366A61K31/343A61K31/215A61K31/192A61P11/04A61P29/00A61P11/00
CPCA61K31/22A61K31/277A61K45/06A61K31/505A61K31/502A61K31/453A61K31/343A61K31/352A61K31/366A61K31/40A61K31/405A61K31/437A61K31/44A61K31/4439A61K2300/00A61P11/00A61K31/4425A61P11/04A61P11/06A61P29/00A61P35/00A61P43/00A61P9/12
Inventor WOLLIN, STEFAN-LUTZ
Owner TAKEDA GMBH
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