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Targeted delivery of botulinum toxin to the sphenopalatine ganglion

a botulinum toxin and sphenopalatine technology, applied in the direction of antibody medical ingredients, peptide/protein ingredients, metabolism disorders, etc., can solve the problems of migraine, referred pain anywhere along the trigeminal network, vision loss and jaw pain, and achieve effective therapeutic and prophylactic treatment of migraines, tac, and other headaches, reducing or preventing symptoms

Active Publication Date: 2008-11-13
ALLERGAN INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent describes a new way to help people who have migraines, tension-related headaches, and similar problems caused by blood flow issues. It involves giving them a special medicine that can reduce or stop those symptoms. This approach uses a specific type of medication called a presynaptic neurotoxin which works by targeting certain nerves near the brain. By doing this, it's hoped that we can offer more effectiveness while also making sure the patient doesn't experience any harmful side effects from the treatment.

Problems solved by technology

The technical problem addressed in this patent text is the development of improved methods for treating migraines and related headaches caused by the use of presynaptic neurotoxins such as Botulinum toxin. Previous research had focused mainly on the intracranial and cervical areas due to their ability to relax facial and neck muscles. The current approach takes advantage of advancements made regarding understanding how the disease triggers specific parts of the body's response.

Method used

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  • Targeted delivery of botulinum toxin to the sphenopalatine ganglion
  • Targeted delivery of botulinum toxin to the sphenopalatine ganglion
  • Targeted delivery of botulinum toxin to the sphenopalatine ganglion

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0067]A 48 yr. old female patient with chronic migraine associated with rhinorrhea and cervical dystonia was treated with the disclosed intranasal method. Her migraines involved the left hemicranium and were associated with left rhinorrhea. Initial Botulinum toxin treatment using migraine and cervical dystonia protocols improved her headaches, but did not completely abort them, while the rhinorrhea persisted. The patient was treated with intranasal injections of BOTOX® 2.5 units (4 cc dilution) four times on the left side only, using the needle palpation approach. There was no change in the shape of the nose or the cartilage base. The discomfort was minimal and the bleeding was not excessive. Two weeks after the treatment, both the rhinorrhea and the headache were resolved.

Temporal Administration

[0068]To target the extracranial trigeminal nerve endings in the temporal region, the extracranial temporal artery is palpated and the skin is marked where the artery's pulsations are felt. ...

example 2

[0084]A female patient presents with chronic migraines. Her migraines involved the right hemicranium. The patient is treated with a sphenopalatine ganglion targeted injection of BOTOX® of about 100 units (in a 1 cc dilution) in a continuous injection method on the right side only, using the disclosed technique, to distribute the toxin around the sphenopalatine ganglion (thus minimizing / avoiding administration of toxin to the temporalis muscle). The discomfort is minimal and the bleeding is not excessive. The patient remains upright (e.g. substantially vertical) after toxin administration (from about 15 min to 3 hours, more preferably from about 1 to about 3 hours and most preferably from about 2 to about 3 hours), to allow toxin to remain concentrated at the sphenopalatine ganglion and not be distributed throughout the temporalis muscle. Two weeks after the treatment, the headache is resolved.

example 3

[0085]A male patient presents with bilateral cluster headaches. The patient is treated with bilateral sphenopalatine ganglion injections of BOTOX® (botulinum toxin type A at 50 units per side, (in a 1 cc dilution, i.e. 50 units per / cc / side) at a plurality of sites along the injection needle track, around the sphenopalatine ganglion (thus minimizing / avoiding administration of toxin to the temporalis muscle). The discomfort is minimal and the bleeding is not excessive. The patient remains upright (e.g. substantially vertical) after toxin administration (from about 15 min to 3 hours, more preferably from about 1 to about 3 hours and most preferably from about 2 to about 3 hours), to allow toxin to remain concentrated at the sphenopalatine ganglion and not be distributed through out the temporalis muscle, as above. Two weeks after the treatment, the headache is resolved.

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Abstract

Botulinum toxin, among other presynaptic neurotoxins is used for the treatment and prevention of migraine and other headaches associated with vascular disorders. Presynaptic neurotoxins are delivered focally, targeting the sphenopalatine ganglion. Exemplary delivery is carried out by way of injection.

Description

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Claims

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Application Information

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Owner ALLERGAN INC
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