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Topical Antiviral Formulations

a technology of antiviral and topical formulations, which is applied in the field of formulations with antiviral activity, can solve the problems of not always using safe-sex techniques, not always using them properly, and not always using current safe-sex techniques, so as to increase the probability of composition us

Inactive Publication Date: 2008-02-14
EASTERN VIRGINIA MEDICAL SCHOOL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention is about a new way to prevent the transmission of HIV through sexual activity. It involves using a nucleotide reverse transcriptase inhibitor (NRTI) called tenofovir or a derivative of it. The NRTI can be applied topically, either vaginally or rectally, and acts as a lubricant during sexual activity. The composition can be used by both heterosexuals and homosexuals, and can also be used as a treatment for bacterial vaginosis. The advantage of this invention is that it offers a simple and effective way to protect against HIV infections."

Problems solved by technology

Human immunodeficiency virus (HIV) infection and related diseases are a major public health problem worldwide.
Even with their known effectiveness in preventing STDs, current safe-sex techniques are not always used, or are not always used properly, for many reasons (e.g. carelessness, lack of knowledge, improper techniques, cultural barriers, unplanned or spontaneous sexual activity, and the like).
Moreover, even when used, safe-sex techniques (except perhaps abstinence) are not always effective.
However, there is no formulation that is totally effective against HIV.

Method used

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  • Topical Antiviral Formulations
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Examples

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examples

[0056] The following examples further describe and demonstrate particular embodiments within the scope of the present invention. The examples are given solely for illustration and are not to be construed as limitations as many variations are possible without departing from spirit and scope of the Invention. The following examples are intended for illustration only and are not intended to limit the scope of the invention in any way. “Active ingredient” denotes one or more NRTIs, as defined above, preferably tenofovir or a physiologically functional derivative thereof.

[0057] Formulation A (Controlled Release Formulation):

[0058] This formulation is prepared by wet granulation of the ingredients with purified water, followed by the addition of magnesium stearate and compression. The hypromellose can utilize varying viscosity grades.

mg / tabletActive ingredient300Hypromellose112Lactose Monohydrate53Pregelatinized Starch28Magnesium Stearate7Purified Waterq.s.

[0059] Drug release takes pl...

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Abstract

The present invention relates to formulations of nucleotide reverse transcriptase inhibitors (N(t)RTIs), preferably [2-(6-Amino-purin-9-yl)-1-methyl-ethoxymethyl]-phosphonic acid (tenofovir, PMPA), or a physiologically functional derivative thereof, suitable for topical application and their use in the prevention of HIV infections.

Description

FIELD OF THE INVENTION [0001] The invention relates generally to formulations of compounds with antiviral activity and more specifically with anti-HIV properties. BACKGROUND OF THE INVENTION [0002] Human immunodeficiency virus (HIV) infection and related diseases are a major public health problem worldwide. One approach to the problem of HIV / AIDS is to reduce the risk of transmission of HIV and thus reduce the number of individuals who become newly infected. Even when treatments or cures become available, prevention of infections in the initial instance will likely remain as the first line of defense. For medical, psychological, and economic reasons, it is preferable to prevent the initial infection, rather than treating, individuals with AIDS. [0003] Education in regard to sexually transmitted diseases (STDs), their modes of transmission, and so-called “safe-sex” techniques has shown some promise in reducing the risks of STD transmission through sexual activity. Screening of the bl...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/675A61F6/04A61P31/00
CPCA61K9/0014A61K9/02A61F6/04A61K31/675A61K31/505A61P15/00A61P31/00A61P31/12A61P31/18A61P43/00A61K9/16A61K9/48A61K9/12A61K9/0034
Inventor DAHL, TERRENCE C.
Owner EASTERN VIRGINIA MEDICAL SCHOOL
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