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Medicament for treatment of nocturia

a technology for nocturia and a treatment method, applied in the direction of drug compositions, biocide, urinary disorders, etc., can solve the problems of insufficient sleep, inability to properly treat nocturia, and major health problems of elderly people with low urnary tract symptoms, etc., and achieve the effect of effective treatment of nocturia

Inactive Publication Date: 2006-10-26
SANKYO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a medicament for the treatment of nocturia that contains a nonsteroidal anti-inflammatory drug (NSAID) as an active ingredient. The inventor found that a patient who was being treated for shoulder pain reported that their nocturia suddenly decreased when they took a tablet of loxoprofen sodium. The inventor conducted a trial treatment with loxoprofen and found that it was effective in treating nocturia. The invention is based on these findings. The medicament can be used preventively or therapeutically and the preferred NSAID is loxoprofen. The invention provides a method for preventing or treating nocturia by administering a nonsteroidal anti-inflammatory drug to a patient in need of such treatment. The use of a nonsteroidal anti-inflammatory drug for this purpose is also provided.

Problems solved by technology

Lower urnary tract symptoms (LUTS) are becoming a major health problem for elderly people worldwide.
Noctia, a cause of insufficient sleep and thus impaired quality of life, is one of the main problems in LUTS along with urinary incontinence and difficulty in urination.
However, in the inventor's experience, about one-half of such patients do not respond well to these medications.

Method used

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Examples

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example

[0016] The present invention will be explained more specifically by way of examples. However, the scope of the present invention is not limited to these examples.

Patients and Methods

[0017] One hundred forty one patients (136 men) aged 49 to 89 (mean 70.5) years with LUTS and =2 voids per night were enrolled in the study. Their main diseases were BPH (n=93), prostate cancer (n=24) and neurogenic bladder (NB) (n-13); 11 had other diseases. The majority of patients had failed to respond to anticholinergic drugs, hypnotics and / or other medications for nocturia prescribed in addition to their treatments for their main diseases. Patients who had asthma, gastrointestinal disorders, renal dysfunction and allergies to lozoprofen were excluded.

[0018] Patients took a single 60 mg loxoprofen tablet prior to sleeping at night for 4 to 14 days initially concurrently with their treatments for their main diseases. Numbers of voids / night as reported by each patient were evaluated and treatment o...

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Abstract

A method for therapeutic treatment of nocturia which comprises administering to a mammal, including a human in need of such treatment, a therapeutically effective amount of loxoprofen or a pharmacologically acceptable salt thereof.

Description

CROSS-REFERENCE TO RELATED APPLICATION [0001] This application is a continuation application of application Ser. No. 10 / 242,754, filed Sep. 13, 2002.FIELD OF THE INTENTION [0002] The present invention relates to a preventive and / or therapeutic treatment of nocturia. RELATED ART [0003] Lower urnary tract symptoms (LUTS) are becoming a major health problem for elderly people worldwide. Noctia, a cause of insufficient sleep and thus impaired quality of life, is one of the main problems in LUTS along with urinary incontinence and difficulty in urination. The aetiology of nocturia is various and complex and obscure in many patients, although LUTS, insomnia, nocturnal polyuria due to cardiovascular or renal hypofunction and disorders of the central nervous system (CNS) may be among the causes (Resnick N. M., et al., Campbell's Urology, 7th edn, Vol.2. Chapt 31. Philadelphia: Saunders, 1998: 1044-58). [0004] The aetiology of nocturia is still obscure in many patients, even in those with BP...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/192
CPCA61K31/192A61K31/19A61P13/00A61P29/00
Inventor ARAKI, TOHRU
Owner SANKYO CO LTD
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