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Composition for accelerating secretion of estrogen and regenerating tissue cells of female sexual organs

a technology of regenerating tissue cells and estrogen, which is applied in the direction of biocide, drug composition, cardiovascular disorder, etc., can solve the problems of increased incidence of breast cancer and metrocarcinoma, complicated metabolism pathway including 2-hydroxyation, and formation of catecholesterogens

Inactive Publication Date: 2006-03-09
NATURALENDO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0026] Furthermore, the present inventors found that the composition comprising Platycodi Radix, Cynanchum wilfordii and Phlomis umbrosa extracts exhibits synergic effect on accelerating estrogen secretion.
[0048] A composition of the present invention not only accelerates estrogen secretion and regenerates or proliferates tissue cells of sexual organs, but also has much less adverse effects than those chemically synthesized since it comprises Platycodi Radix and Cynanchum wilfordii extracts and / or Phlomis umbrosa extract used traditionally as oriental pharmaceuticals.

Problems solved by technology

The metabolic pathway including 2-hydroxyation is more complicated and results in the formation of catecholesterogen.
However, the problem is that such a hormone replacement therapy may increase the activity of cancer-inducing gene, leading to increased incidence rate of breast cancer and metrocarcinoma, etc.
However, as the source of the product is horse urine, the patient compliance is far poor.

Method used

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  • Composition for accelerating secretion of estrogen and regenerating tissue cells of female sexual organs
  • Composition for accelerating secretion of estrogen and regenerating tissue cells of female sexual organs

Examples

Experimental program
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Effect test

example 1

Preparation of Composition Containing Platycodi Radix Extract

example 1-1

Preparation of Low Molecular Weight-Extract of Platycodi Radix Using Ultrafiltration Membrane

[0054] To 50 g of dried Platycodi Radix, 1.5 liters of distilled water were added, followed by heating for 2 hr over room temperature for extraction, thereby obtaining aqueous extract. The extract was concentrated to final volume of 500 ml.

[0055] The extract was centrifuged at 3000 rmp for 10 min. after which for filtration the supernatant obtained was passed through ultrafiltration membrane with molecular weight cut off (MWCO) of 100, 000 by means of stirred cell apparatus (purchased from Amicon, USA). The nitrogen gas pressure used was fixed at 3 atm. The extract was dried to give powder of which the amount is shown in Table 1 below.

TABLE 1ExtractionStepWeight (g)Efficiency (%)Raw materials50100Extract1428Filtration with MWCO11.523of 100,000

example 1-2

Preparation of Composition for Oral Administration

[0056] The composition for oral administration containing Platycodi Radix extract was prepared with ingredients as in Table 2.

TABLE 2AmountIngredients(Weight %)Platycodi Radix extracts50Calcium from marine algae24Arginine16Lysine10

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Abstract

The present invention relates to a composition for accelerating secretion of estrogen and regenerating tissue cells of female sexual organs, more particularly; to a composition for accelerating secretion of estrogen and regenerating tissue cells of female sexual organs in postmenopausal women comprising one or more of Platycodi Radix and Cynanchum wilfordii extract and / or Phlomis umbrosa extract. The present invention provides a composition, a pharmaceutical composition and a food composition capable of replacing estrogen, which comprise one or more selected from the group consisting of Platycodi Radix extract and Cynanchum wilfordii extract and / or Phlomis umbrosa extract. The composition of this invention comprised of the extracts of natural source shows little or no adverse effects such as cancer occurrence compared with estrogen-replacing agent used for conventional hormone replacement therapy; in addition, it has excellent effect on the regeneration and proliferation of tissue cells of female sexual organs, so that it is applicable to treatment of various disorders and diseases developed in postmenopausal women who are deficient in estrogen. Moreover, the composition of this invention has little impurities and high amount of active ingredients.

Description

FIELD OF THE INVENTION [0001] The present invention relates to a composition for accelerating secretion of estrogen and regenerating tissue cells of female sexual organs, more particularly, to a composition for accelerating secretion of estrogen and regenerating tissue cells of female sexual organs in postmenopausal women comprising one or more selected from the group consisting of Platycodi Radix extract and Cynanchum wilfordii extract and / or Phlomis umbrosa extract. BACKGROUD OF THE INVENTION [0002] A hormone secreted from follicles in ovaries, estrogen, develops sexual organs and makes them functional to exhibit the secondary sexual character and accelerate the development of uterus, the proliferation of endometrium, the development of mammary gland and regular menstruation. In addition to ovaries, estrogen is secreted from placenta, adrenal cortex and testis in a small amount. Three types of steroids, estrone, estradiol and estriol found in body are known. [0003] Estrogen is pro...

Claims

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Application Information

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IPC IPC(8): A61K36/346A61K36/88A23L1/30A23L1/304A23L33/15A61K31/198A61K33/06A61K36/00A61K36/18A61K36/232A61K36/27A61K36/53A61K36/70A61P1/02A61P5/24A61P5/30A61P9/00A61P13/12A61P15/00A61P15/08A61P15/12A61P17/16A61P19/08A61P25/28A61P43/00
CPCA23L1/3002A23L1/302A23L1/304A23V2002/00A61K36/232A61K36/53A61K36/27A61K36/346A61K2300/00A23V2250/21A23V2200/30A23V2200/306A23V2250/70A23V2250/156A23L33/105A23L33/15A23L33/16A61P1/02A61P13/12A61P15/00A61P15/08A61P15/12A61P17/16A61P19/08A61P25/28A61P43/00A61P5/24A61P5/30A61P9/00
Inventor KIM, JAE-SOO
Owner NATURALENDO TECH
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