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Compositions for treating biofilm

a biofilm and composition technology, applied in the direction of heterocyclic compound active ingredients, peptide/protein ingredients, organic active ingredients, etc., can solve the problem of not achieving complete cellular kill within the biofilm structure by chemical or physical agents, and achieve the effect of reducing the opportunity for gene transfer, increasing the free-flow of nutrients, and increasing the penetration of chemical agents

Inactive Publication Date: 2005-07-21
PHARMACAL BIOTECHNOLOGIES INC
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The enzyme complexes effectively disrupt biofilms, enhancing antibiotic penetration and metabolic activity, making bacteria more susceptible to antimicrobials and host immune responses, while preventing reformation, thus addressing resistance and recalcitrance.

Problems solved by technology

Unless the biofilm is removed or disrupted, complete cellular kill within the biofilm structure is not achieved by chemical or physical agents.

Method used

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  • Compositions for treating biofilm
  • Compositions for treating biofilm

Examples

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[0126] Since P. aeruginosa is a ubiquitous bacterial strain, found not only in the environment and in industrial settings where fouling occurs, but also in many disease conditions, it will serve as an example to illustrate the principles of the invention. Further, while there are many disease conditions for which P. aeruginosa is the cause, ocular infections will exemplify the implementation of the invention. The choice of P. aeruginosa as the biofilm-producing bacteria and pathogen and ocular infection as a consequence of the biofilm is not meant to preclude or limit the scope of this invention. The principles outlined in this example readily apply to all biofilms, whether produced by bacteria or other organisms, all biofilms that are generated by organisms and the embodiments, taken and implemented either individually or collectively.

[0127]P. aeruginosa is an opportunistic bacterial species, which once colonized at a site such as ocular tissue, produces a biofilm with a polysacch...

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Abstract

A two component composition comprises an anchor enzyme complex to degrade biofilm structures and a second anchor enzyme component having the capability to act directly upon the bacteria for a bactericidal effect.

Description

CROSS REFERENCE TO THE RELATED APPLICATIONS [0001] This application is a continuation of U.S. application Ser. No. 09 / 587,818 filed Jun. 6, 2000, which is a continuation-in-part of U.S. application Ser. No. 09 / 249,674 filed Feb. 12, 1999, which is a continuation-in-part of U.S. application Ser. No. 08 / 951,393 filed Oct. 16, 1997 (issued as U.S. Pat. No. 5,871,714 on Feb. 16, 1999), all of which are incorporated herein by reference.FIELD AND BACKGROUND OF THE INVENTION [0002] Standard chemical analyses, traditional microscopic methods as well as digital imaging techniques such as confocal scanning laser microscopy, have transformed the structural and functional understanding of biofilms. Investigators, with these techniques have a clearer understanding of biofilm-associated microorganism cell morphology and cellular functions. The heightened awareness of metabolic biochemistry and the events associated with them have led to a better understanding, not only of individual cells and the...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/64A61K8/66A61K31/43A61K31/545A61K31/715A61K38/00A61K38/47A61K47/48A61Q11/00
CPCA61K8/64A61K8/66A61K31/43A61K31/545A61Q17/005A61K38/47A61K47/48238A61K2800/57A61Q11/00A61K31/715A61K47/62
Inventor BUDNY, JOHN A.BUDNY, MATTHEW J.
Owner PHARMACAL BIOTECHNOLOGIES INC
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