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Inhibition of abnormal cell proliferation with camptothecin and combinations including the same

a technology of camptothecin and cell proliferation, which is applied in the direction of angiogenin, drug composition, cardiovascular disorders, etc., can solve the problems of high toxicity, low potency, and later abandonment of studies

Inactive Publication Date: 2005-06-02
SUPERGEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0026] An adjuvant may be used to augment the immune response to TAAs. Examples of adjuvants include, but are not limited to, bacillus Calmette-Guerin (BCG), endotoxin lipopolysaccharides, keyhole limpet hemocyanin (GKLH), interleukin-2 (IL-2), granulocyte-macrophage colony-stimulating factor (GM-CSF) and cytoxan, a chemotherapeutic agent which is believe to reduce tumor-induced suppression when given in low doses.

Problems solved by technology

The studies were later abandoned because of the high toxicity and low potency of 20(S)-camptothecin Na+.

Method used

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Examples

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Embodiment Construction

1. Camptothecin Compounds (CPT)

[0035] The class of camptothecin compounds referred to herein as CPT include various 20(S)-camptothecins, analogs of 20(S)-camptothecin, derivatives of 20(S)-camptothecin, prodrugs of 20(S)-camptothecin, and pharmaceutically active metabolites of 20(S)-camptothecin. Camptothecin, when used in the context of this invention, includes the plant alkaloid 20(S)-camptothecin, both substituted and unsubstituted camptothecins, and analogs thereof. Examples of camptothecin derivatives include, but are not limited to, 9-nitro-20(S)-camptothecin, 9-amino-20(S)-camptothecin, 9-methyl-camptothecin, 9-chloro-camptothecin, 9-flouro-camptothecin, 7-ethyl camptothecin, 10-methyl-camptothecin, 10-chloro-camptothecin, 10-bromo-camptothecin, 10-fluoro-camptothecin, 9-methoxy-camptothecin, 11-fluoro-camptothecin, 7-ethyl-10-hydroxy camptothecin, 10,11-methylenedioxy camptothecin, and 10,11-ethylenedioxy camptothecin, and 7-(4-methylpiperazinomethylene)-10,11-methylenedio...

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Abstract

A method for treating diseases associated with abnormal cell proliferation comprises delivering to a patient in need of treatment a compound selected from the group consisting of 20(S)-camptothecin, analog of 20(S)-camptothecin, derivative of 20(S)-camptothecin, prodrug of 20(S)-camptothecin, and pharmaceutically active metabolite of 20(S)-camptothecin, in combination with an effective amount of one or more agents selected from the group consisting of alkylating agent, antibiotic agent, an alkylating agent, antibiotic agent, antimetabolic agent, hormonal agent, plant-derived agent, anti-angiogenesis agent and biologic agent. The method can be used to treat benign tumors, malignant or metastatic tumors, leukemia and diseases associated with abnormal angiogenesis.

Description

CROSS-REFERENCE TO RELATED APPLICATION [0001] This application is a continuation of application Ser. No. 10 / 127,956, filed Apr. 22, 2002, which is a continuation of application Ser. No. 09 / 553,710 filed on Apr. 20, 2000, which is a continuation-in-part of application Ser. No. 09 / 418,862 filed Oct. 15, 1999. These applications are incorporated herein by reference in their entirety.BACKGROUND OF THE INVENTION [0002] 1. Field of the Invention [0003] This invention relates to a method for treating diseases using a camptothecin, and more specifically a method for treating diseases associated with abnormal cell growth using a camptothecin alone or in combination with another drug. [0004] 2. Description of Related Art [0005] 20(S)-camptothecin, a plant alkaloid, was found to have anticancer activity in the late 1950's. Wall, M. et al., Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata, J. Am. C...

Claims

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Application Information

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IPC IPC(8): A61K31/44A61K31/4745A61K31/70A61K45/06
CPCA61K31/44A61K31/4745A61K31/70A61K45/06A61K2300/00A61P35/00
Inventor RUBINFELD, JOSEPH
Owner SUPERGEN
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