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Method for the detection of risk factors associated with myocardial infarction

a risk factor and myocardial infarction technology, applied in the field of myocardial infarction, can solve the problems and achieve the effect of increasing the risk of myocardial infarction

Inactive Publication Date: 2005-02-03
GENESIS GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0027] In accordance with another aspect of the present invention, there is provided a method for determining whether an individual is at an increased risk for myocardial infarction, comprising determining physiochemical activity of gene pro

Problems solved by technology

These methods comprise assaying a suitable biological sample and determining the presence or absence of variant genetic elements, their gene products, or altered physiochemical activities of these gene products correlated with elevated risk of myocardial infarction.

Method used

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  • Method for the detection of risk factors associated with myocardial infarction
  • Method for the detection of risk factors associated with myocardial infarction
  • Method for the detection of risk factors associated with myocardial infarction

Examples

Experimental program
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example 1

[0094] Subjects, Materials and Methods

[0095] Subjects:

[0096] Blood samples were collected from 500 consecutive myocardial infarction patients and 500 normal controls of the genetically isolated Newfoundland population. The population consists mainly of descendants of English and Irish settlers who arrived in the 18th and 19th centuries. The geographic and social isolation of the island has ensured very little inward migration for several hundred years, and thus has lead to a small population (530,000 individuals) with a relatively homogenous genetic background, ideal for the study of complex multifactorial diseases such as myocardial infarction.

[0097] Patients categorized in the myocardial infarction group represented those presenting to the emergency department or within one of the Health Care Corporation of St. John's hospitals with symptoms and biochemical evidence suggestive of myocardial infarction. Only patients with cardiac Troponin I values greater than 2.0 μg / L (Axsym, A...

example 2

[0120] Subjects, Materials and Methods

[0121] Blood samples were collected from 230 additional patients with MI and 79 additional normal controls, using the methods and m,aterials set out in Example 1. The cumulative summary of the results based total 730 patients with MI and 579 normal controls are given in the following tables and figures:

[0122] Results

[0123] Genotyping FIIG20210A, FVL and FXIII-A V34L

[0124] The genotype distributions, carrier frequencies, and allele frequencies of FII 20210A, FVL, and FXIII-A L34 in both the MI patient and the control populations are given in Table 3: distributions of genotypes, and carrier and allele frequencies of FIIG20210A, FVL and FXIII-A V34L in MI patient and normal control populations. (MI: myocardial infarction, NC: normal control, OR: odds ratio).

GenotypeMI (n = 730)NC (n = 579)OR (95% CI)P valueFIIG20210AG / G710 (97.3%)572 (98.8%)G / A 20 (2.7%) 7 (1.2%)A / A 0 (0%) 0 (0%)Carrier F. 2.7% 1.2%2.302 (0.967, 5.482)0.053Allele F. 1.4% 0.6%...

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Abstract

A method for determining whether an individual is at an increased risk for myocardial infarction, comprising screening for the presence of Factor II and Factor XIII alleles associated with myocardial infarction. Also provided are kits and primers that specifically hybridize adjacent to the allele-specific regions of the Factor II and Factor XIII genes.

Description

FIELD OF THE INVENTION [0001] The present invention relates to the field of myocardial infarction, more particularly, the invention is directed at a method for determining the risk for myocardial infarction in an individual. BACKGROUND OF THE INVENTION [0002] Myocardial infarction (MI) is now among the most frequent causes of illness and death, especially in the industrial countries. If myocardial infarction is survived, the vitality of the patient is limited in most cases, by secondary symptoms such as paralysis or organ damage. There are also labor-intensive and cost-intensive follow-up treatments, such as convalescence, physiotherapy and medication to improve the health situation and prevent further complications. [0003] Great advances have been made in recent years, especially in research into the causes of myocardial infarction, and these include cardiac tissue necrosis caused by an inadequate blood supply due to the occlusion of arterial blood vessels either by cholesterol pla...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
CPCC12Q1/6883C12Q1/6827
Inventor XIE, YA-GANG
Owner GENESIS GROUP
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