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Prevention of hyperinsulinemia in subjects undergoing growth hormone (GH) treatment

a growth hormone and hyperinsulinemia technology, applied in the direction of drug compositions, peptide/protein ingredients, metabolic disorders, etc., can solve the problems of increasing the risk of overt type 2 diabetes in susceptible obese individuals, and achieve the effects of stimulating lipid clearance, reducing blood lipid levels, and reducing the level of on

Inactive Publication Date: 2005-01-06
NOVO NORDISK AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention relates to a method for preventing hyperinsulinemia in subjects undergoing treatment with growth hormone (GH) by modulating diet composition and caloric intake, or by administering a drug that reduces blood lipid levels. The invention also includes methods for reducing adipose tissue loss and serum leptin levels, as well as stimulating lipid clearance from circulation. The invention further includes medical kits for use in the methods. The technical effects of the invention include reducing the risk of insulin resistance and compensatory hyper-secretion of insulin, and improving the metabolic profile of subjects undergoing GH treatment.

Problems solved by technology

Moreover, sustained hyperinsulinemia would also increase the risk of development of overt Type 2 diabetes in susceptible obese individuals that already are at risk.

Method used

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  • Prevention of hyperinsulinemia in subjects undergoing growth hormone (GH) treatment
  • Prevention of hyperinsulinemia in subjects undergoing growth hormone (GH) treatment
  • Prevention of hyperinsulinemia in subjects undergoing growth hormone (GH) treatment

Examples

Experimental program
Comparison scheme
Effect test

example 1

Effects of Diet and GH on Body Composition, Blood Lipids, and Insulin

[0052] The following experiments were performed in order to evaluate the effect of varying diet on the effect of GH administration on insulin levels and other metabolic parameters.

Materials and Methods

[0053] Animals and Test Substances

[0054] Female Wistar rats weighing about 260 g were purchased 1 month before the start of experiments from Møllegård Breeding and Research Centre (Lille Skensved, Denmark). On arrival, rats were placed in conventional rat cages housing 2-3 animals. They were weighed weekly, and had free access to drinking water and a standard rat feed. All diets, including the experimental diets (see Table 1, below), were purchased from a local feed supplier (Brogaarden, Gentofte, Denmark). The experimental protocol was approved by the Danish national ethical committee for animal experiments (Dyreforsøgstilsynet, Copenhagen, Denmark). The growth hormone (GH) used in the present study was recombina...

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Abstract

The present invention provides methods and compositions for preventing hyperinsulinemia that can result from therapeutic administration of growth hormone. The methods are carried out by imposing a restricted high-fat diet and / or by administering one or more drugs that lower serum lipids.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application claims priority under 35 U.S.C. 119 of Danish application no. PA 2003 00548 filed Apr. 9, 2003 and U.S. application Ser. No. 60 / 467,079 filed May 1, 2003, the contents of which are fully incorporated herein by reference.BACKGROUND OF THE INVENTION [0002] Obesity is known to be associated with serious risk factors, and there is currently intense interest in identifying new principles for treatment of this condition. These efforts have hitherto resulted in identification of a substantial number of potential central and peripheral targets for treatment. It has also been shown that growth hormone (GH), more specifically human growth hormone (hGH) in human beings, acts as a potent regulator of body fat storage, and thus promotes breakdown of adipose tissue in obese humans while preserving lean tissues. Since a large proportion of glucose disposal and energy expenditure is thought to take place in lean tissues, preservation o...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A23L33/00A61K31/4965A61K38/27A61K38/55
CPCA23L1/293A61K31/4965A61K38/27A61K38/553A61K2300/00A23L33/30
Inventor JOHANSEN, THUEMALMLOF, KJELL
Owner NOVO NORDISK AS
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