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Method and system for registration, identifying and processing of drug specific data

a technology of drug specific data and system, applied in chemical methods analysis, instruments, molecular structures, etc., can solve the problems of insufficient reliability and security of current methods and systems used for access control of drug delivery for routine medical treatmen

Inactive Publication Date: 2002-07-18
THERASTRAT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0076] The system and method according to the invention has enormous advantages. Thus, the pharmaceutical industries can screen their new products for adverse drug reactions in a simple and secure manner. Moreover, the data of the two data-bases of the system can be relatively simply updated and can be offered to various users on a data medium or by Internet or on Intranet. All in all, the method according to the invention also simplifies the search tasks of the industries to find out possible adverse reactions of drugs in development, so that it can, with high probability, be avoided that a drug has do be withdrawn from the market because of adverse drug reactions after coming onto the market.

Problems solved by technology

Current methods and systems being used for access control of drug delivery are not sufficiently reliable and secure for the routine medical treatment of patients with drugs.

Method used

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  • Method and system for registration, identifying and processing of drug specific data
  • Method and system for registration, identifying and processing of drug specific data

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Embodiment Construction

[0020] It is generally known that the development of most drug-related adverse effects in man is based on the genetic and epigenetic predisposition, i.e. susceptibility of each individual. This predisposition is reflected in predictive patterns of structural properties, genetic polymorphisms and gene expression profiles that correlate with the development of drug related adverse effects.

[0021] The genetic predisposition is phenotypically revealed only when the individual carrier is exposed to (the) offending agent(s) or structural mimics thereof.

[0022] According to the present invention, the master database is stored on a separate server. In accordance with the invention the system also comprises a predictive data-tool in electronic from. In this tool the structural and genetic fingerprints predictive for given adverse effects in individual patients due to treatment with a selected drug are stored.

[0023] Each individual patient-specific data in reality comprises a set of selected ye...

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Abstract

The invention relates to a method for registration, identifying and processing of drug specific data and for making drugs available to individual patients without severe adverse drug reactions. The invention relates also to a system for carrying out such a method. According to the present invention, the system comprises a master database correlating patterns of gene expression and genetic polymorphisms with drug-induced i.e. drug-related adverse effects and drug structure. The system also comprises a predictive data-tool. In this tool the structural and genetic fingerprints predictive for adverse effects in individual patients due to treatment with a selected drug are stored. The method according the invention is characterized in that the master database being coupled to the database of the predictive data-tool in such a way that a user of the system can develop and carry out different screening approaches either to verify the sociability of drugs for a specific selected category of patients or to search a specific drug for a selected category of patients which do not have adverse drug reactions or to make risk-analyses.

Description

[0001] 1. Field of the Invention[0002] The invention relates to a method for registration, identifying and processing of drug specific data and for making drugs available to individual patients avoiding adverse drug reactions (ADR). The invention relates also to a system for carrying out such a method.[0003] 2. Description of the Prior Art[0004] Current methods and systems being used for access control of drug delivery are not sufficiently reliable and secure for the routine medical treatment of patients with drugs.[0005] Thus, more than 2 million adverse drug reactions occur annually in the United States. An analysis of 39 prospective studies (JAMA 1998, 279, 1200-1205) shows that in 1994 2,216,000 patients have been hospitalised with adverse drug reactions, 106,000 patients of them with fatal outcome.[0006] Recent examples of drugs affected by severe ADR include the following:1 Drug Reaction Troglitazone Rezulin Anti-diabetes type II drug; severe liver toxicity, unexpected deaths;...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): G16B50/30G16B15/00G16B20/20G16B25/00G16B40/00
CPCG06F19/16G06F19/18G06F19/20G06F19/22G06F19/24G06F19/28G16B15/00G16B20/00G16B25/00G16B30/00G16B40/00G16B50/00G16B20/20G16B50/30
Inventor GUT, J.BAGATTO, DARIO
Owner THERASTRAT
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