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Multivariate analysis of green to ultraviolet spectra of cell and tissue samples

a cell and tissue sample, multi-variate analysis technology, applied in the direction of fluorescence/phosphorescence, instruments, catheters, etc., can solve the problems of difficult to distinguish changes or variations in the spectra, complicated analysis of collected spectra,

Inactive Publication Date: 2001-10-25
ARGOSE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Analysis of collected spectra is complicated by the fact that it can be difficult to distinguish changes or variations in the spectra due to skin variables, such as skin inhomogeneity, UV damage, age, erythema, and the like.

Method used

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Embodiment Construction

[0015] As embodied and broadly described herein, the present invention is directed to the processing of in vivo skin auto-fluorescence spectra for the purposes of determining blood glucose levels. In-vivo fluorescence spectra have been shown to correlate with blood glucose levels. See, Id. Although large changes in skin fluorescence spectra due to changes in blood glucose levels have been observed, it can sometimes be difficult to separate the variations in the spectra caused by changes in blood glucose from other spectral changes due to factors such as skin inhomogeneity, age effects, UV damage, erythema, etc.

[0016] For large subject populations, it is desirable to be able to determine an algorithm for converting skin fluorescence spectra into glucose values which works on a large percentage of the population as opposed to a single individual. Thus, there is a need for an analysis method that takes into account more spectral information than that which is found at a single waveleng...

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PUM

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Abstract

This invention relates to methods for processing in vivo skin auto-fluorescence spectra for determining blood glucose levels. The invention also relates to methods of classifying cells or tissue samples or quantifying a component of a cell or tissue using a multivariate classification or quantification model.

Description

[0001] The present invention claims priority to U.S. Provisional Patent Application No. 60 / 183,356, filed Feb. 18, 2000, and titled "Multivariate Analysis of Green to Ultraviolet Spectra of Cell and Tissue Samples."[0002] 1. Field of the Invention[0003] This invention relates to analysis methodology and multivariate classification of diagnostic spectra, and, in particular, to methods for processing in vivo skin auto-fluorescence spectra for determining blood glucose levels. The invention also relates to methods of classifying cells or tissue samples or quantifying a component of a cell or tissue using a multivariate classification or quantification model.[0004] 2. Description of the Background[0005] Near-IR spectra taken from agricultural samples, such as grains, oil, seeds and feeds, etc., have been used to quantitate various bulk constituents, e.g., total protein, water content, or fat content. See, P. Williams et al., "Agricultural Applications of Near-IR Spectroscopy and PLS Pro...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B5/00A61B5/103A61B5/145A61B5/1455A61B5/1459G01N21/27G01N21/64G01N33/483G01N33/66
CPCA61B5/0059A61B5/0071A61B5/14532A61B5/1455A61B5/441A61B5/445A61B5/7264G01N21/6486G01J3/28G01N2201/129G16H50/20
Inventor MANSFIELD, JAMESFREEMAN, JENNY
Owner ARGOSE
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