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Artificial biological spinal cord

A biotype, spinal cord technology, applied in the fields of microorganisms, biochemical equipment and methods, genetic engineering, etc., to achieve good matrix and microenvironment, no immune rejection, and good biocompatibility.

Active Publication Date: 2007-06-27
SUMMIT GD BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But there is no such device in the prior art

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  • Artificial biological spinal cord

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Embodiment

[0025] Example: As shown in Figure 1, the bioartificial spinal cord is composed of medulla 1, pia mater 2 wrapped outside the medulla 1, a spiral stent 6 fixed outside the pia mater 2, and sequentially wrapped outside the spiral stent 6 The arachnoid membrane 3, the collagen gel layer 5 wrapped around the arachnoid membrane 3, and the dura mater 4 wrapped outside the gel layer 5 are composed. The medulla 1, the pia mater 2, the arachnoid 3 and the dura mater 4 are respectively made of animal spinal cord and animal membrane tissues which are fixed by cross-linking with non-aldehyde fixatives and fixed with active reagents and strong hydrogen bond reagents to remove antigens. Its preparation steps are:

[0026] 1. Preparation of medulla 1: Take fresh porcine spinal cord, carefully cut off its dura, arachnoid and pia mater, take medulla, carefully remove microvessels, put it in 0.2-2% NaOH solution for 2 hours, Remove and rinse three times with water. Remove and drain the water...

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Abstract

The artificial biological spinal cord consists of a medulla, a spinal pia mater coating the medulla, a spiral rack fixed on the spinal pia mater, an arachnoid coating the spiral rack, a collagen gel layer coating arachnoid, and a sinal dura mater coating the collagen gel layer. The medulla, the spinal pia mater, the arachnoid and the sinal dura mater are cross-linked and fixed with no-aldehyde fixing agent, and made of animal spinal cord and membrane tissue with the antigen eliminated by using active reagent and strong hydrogen bond reagent. The present invention is designed through imitating the composition and structure of human spinal cord and made of natural biological material, and possesses the advantages of high biocompatibility, no immunogenicity, capacity of being degraded and absorbed, and capacity of inducing tissue regeneration. The present invention provides excellent matrix and micro environment for repairing spinal cord.

Description

technical field [0001] The invention relates to a medical device for spinal cord reconstruction for spinal cord injury patients, which belongs to the implanted medical device. Background technique [0002] Spinal cord injury often causes paralysis, which is one of the serious injuries. Although it is not immediately life-threatening, it can make the patient disabled for life, and life is better than death. No effective treatment has been found so far. In the past, it was believed that spinal nerves could not be regenerated, and spinal cord injury was an incurable disease. In recent years, it has been found that the central nervous system, including spinal nerves, can be regenerated under suitable conditions. The key is to have a temporary matrix and a good microenvironment suitable for nerve tissue regeneration and reconstruction. The so-called temporary matrix here is a hotbed for the division, proliferation and migration of neural stem cells and their differentiated neur...

Claims

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Application Information

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IPC IPC(8): A61F2/02A61B17/00A61L27/00A61L27/22A61L27/38A61L27/58A61L31/00C12N5/06C12N5/08C12N15/06C12N15/07
Inventor 徐国风
Owner SUMMIT GD BIOTECH
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