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Application of extractive of Daliangjiang, and application in medication

An extract, the technology of galangal, applied in the field of galangal extract and its application in medicine, can solve the problems of toxic drugs and so on

Inactive Publication Date: 2007-05-09
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although neomycin and berbericin have significant biological activity in vitro, both are unsuitable for development as drugs due to their extreme toxicity

Method used

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  • Application of extractive of Daliangjiang, and application in medication
  • Application of extractive of Daliangjiang, and application in medication
  • Application of extractive of Daliangjiang, and application in medication

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Take galangal, chop it, crush it into a coarse powder, heat and reflux with 8 times the amount of 75% ethanol to extract twice, each time for 2 hours, combine the secondary extracts, recover the ethanol under reduced pressure, and obtain the extract; the extract is used, etc. 10:1 n-hexane-ethyl acetate extractant was extracted for 3 times, the extractant was reclaimed under reduced pressure, and the extract was collected; The eluent was eluted, separated and purified, the eluate was collected, dried under reduced pressure and vacuum, and Daliang extract 1 was obtained. The galanga extract 1 is prepared into soft capsules, dropping pills, tablets, capsules, suppositories, aerosols, sprays, powder sprays, microcapsules, liposome preparations, and injections by conventional preparation methods.

Embodiment 2

[0053] Get galangal, chop it, pulverize it into coarse powder, use 5 times the amount of 80% ethanol to heat and reflux extract 2 times, each time for 1.5 hours, combine the secondary extracts, recover the ethanol under reduced pressure, and obtain the extract; extract the extract with 2 Double the amount of 5:1 n-hexane-ethyl acetate extractant to extract twice, recover the extractant under reduced pressure, and collect the extract; For separation and purification by eluent elution, the eluate was collected and dried under reduced pressure to obtain Daliang extract 2. The galanga extract 2 is made into soft capsules, dropping pills, tablets, capsules, suppositories, aerosols, sprays, powder sprays, microcapsules, liposome preparations, and injections by conventional preparation methods.

Embodiment 3

[0055] Get galangal, chop it, pulverize it into coarse powder, heat and reflux extract with 10 times the amount of 50% ethanol for 2 times, each time for 3 hours, combine the secondary extracts, recover the ethanol under reduced pressure, and obtain the extract; the extract is used for 5 Double the amount of 2:1 n-hexane-ethyl acetate extractant to extract 3 times, recover the extractant under reduced pressure, and collect the extract; For separation and purification by eluent elution, the eluate was collected and dried under reduced pressure to obtain Daliang extract 3. The galanga extract 3 is prepared into soft capsules, dropping pills, tablets, capsules, suppositories, aerosols, sprays, powder sprays, microcapsules, liposome preparations, and injections by conventional preparation methods.

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PUM

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Abstract

An application of the extract of alpinia galanga rhizome in preparing the Rev protein depressant for preventing and treating HIV infection and the medicine for preventing and treating the infection of tuberculous bacillus is disclosed. A process for preparing said extract is also disclosed.

Description

technical field [0001] The present invention relates to the alcohol extract, supercritical CO 2 Extraction extract and steam distillation extract and extraction preparation method, main components and quality control method of galanga extract and preparation made of galangal extract and preparation of new target Rev protein inhibitor anti-HIV infection drug and anti-HIV infection Drug application in tuberculosis infection. Background technique [0002] Galangal, also known as Galangal, Galangal, Alpinia galangal, Alpinia galangalis, and Lianjiang, is the rhizome of Alpinia galanga Willd., a plant of the genus Zingiberaceae. Galangal grows in tropical and subtropical climates, and is mainly distributed in Guangdong, Guangxi, Hainan, Taiwan, Yunnan and other provinces in my country. [0003] Galangal (red cardamom) was first recorded in "Medicine Properties", which is said to cure mainly: "Abdominal pain due to cold air, eliminate miasma and poisonous gas, remove food, warm ...

Claims

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Application Information

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IPC IPC(8): A61K36/9064A61K9/02A61K9/08A61K9/12A61K9/127A61K9/20A61K9/48A61K9/50A61P31/06A61K125/00
Inventor 叶英刘孝乐钱进许军彭红陶琳
Owner HONGYI SCI & TECH CO LTD NANCHANG
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