External preparation of Levocetirizine hydrochloric acid

Abstract

An exterior-applied levocetirizine hydrochloride for preventing and treating the anaphylaxia and inflammation without untoward effect is disclosed.

Description

Technical field [0001] The invention belongs to the technology of pharmaceutical preparations. Background technique [0002] With the change of climate and environment, various harmful gases, dust and other pollution sources emerge in large numbers, which become allergens that cause people to have various allergic reactions. Seasonal changes, field work, pollen allergies, inhalation of harmful gases and dust particles, etc., have caused more and more people to suffer from various types of allergic diseases, allergic rhinitis, urticaria, skin redness, itching, redness Asthma caused by spots and allergens is very common. Therefore, it is very important to develop drugs for the treatment of allergic diseases. [0003] At present, the second-generation antihistamine drugs are mainly used in the clinical treatment of allergic diseases, among which cetirizine has the strongest drug activity, has better anti-inflammatory and anti-allergic effects, and has the highest bioavailabil...

AI Technical Summary

Problems solved by technology

[0008] 3. Levocetirizine hydrochloride has rapid absorption in vivo, limited distribution and low metabolic rate;

However, the blood flow distribution of skin tissue is relatively small, which makes the tissue distribution of levocetirizine hydrochloride very unfavorable for its treatment of skin allergic diseases and dermatitis, and is applied to skin diseases through oral administration in large doses , it will inevitably bring some unexpected serious systemic adverse reactions, which is a very unsatisfactory way of administration